ArticleThe Journal of physiology2018
Effects of elevated H
Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 5 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Sex differences in human skeletal muscle fiber types and the influence of age, physical activity, and muscle group: A systematic review and meta-analysis.Physiological reports · 2025Pooled it
- Effects of age on human skeletal muscle: a systematic review and meta-analysis of myosin heavy chain isoform protein expression, fiber size, and distribution.American journal of physiology. Cell physiology · 2024Pooled it
- Pooled it
- Extracellular Buffering Supplements to Improve Exercise Capacity and Performance: A Comprehensive Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Age-related Deficits in Voluntary Activation: A Systematic Review and Meta-analysis.Medicine and science in sports and exercise · 2020Pooled it
- Trial
- Delaying task failure in high-intensity exercise: a Pi-afferent-effort framework for targeted sports nutrition.Journal of the International Society of Sports Nutrition · 2026Review
- Macroscopic to ultrastructural analyses identify the loss of myofibrils as the primary mediator of ageing- and disuse-induced muscle fibre atrophy.The Journal of physiology · 2026Article
- Phosphate and acidosis cause fibre type-specific changes to cellular and molecular contractile mechanics at 37°C in skeletal muscle from older adults.Experimental physiology · 2026Article
- Isometric slow- and fast-contracting skeletal muscle fibres have more similar cellular and molecular properties at 37°C than at 25°C in older adults.The Journal of physiology · 2026Article
- Three-dimensional imaging reveals preserved intrinsic contractile function in aging human skeletal muscle fibers.bioRxiv : the preprint server for biology · 2026Article
- The other half of the sprinting coin: the neuromuscular profile of a 91-yr-old female world record sprinter.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Initial contractions of a single-load fatiguing exercise provide a valid assessment of age-related differences in peak power.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- pH-Resolved ATP Synthesis in Skeletal Muscle: Concept, Implementation, and Assessment Using DynamicDiagnostics (Basel, Switzerland) · 2026Article
- Myonuclear loss, rather than senescent myonuclei, associates with fiber type-specific atrophy in aging human skeletal muscle.bioRxiv : the preprint server for biology · 2026Article
- Effects of acidosis and inorganic phosphate on CaAmerican journal of physiology. Cell physiology · 2026Article
- Cross-bridge model-based quantification of muscle metabolite alterations leading to fatigue during all-out knee extension exercise.Frontiers in physiology · 2026Article
- Motor performance and aging in males and females.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2025Review
- The independent effects of age and sex in performance fatigability profile after a ramp incremental cycling test.European journal of applied physiology · 2025Article
- Mechanisms for the age-related increase in fatigability of the elbow flexor muscles in healthy adults.Physiological reports · 2025Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
key pointsThe mechanisms responsible for the loss in muscle power and increased fatigability with ageing are unresolved. We show that the contractile mechanics of fibres from the vastus lateralis of old men were well-preserved compared to those of young men, but the selective loss of fast myosin heavy chain II muscle was strongly associated with age-related decrements in whole-muscle strength and power. We reveal that the combination of acidosis (H ABSTRACT: The present study aimed to identify the mechanisms responsible for the loss in muscle power and increased fatigability with ageing by integrating measures of whole-muscle function with single fibre contractile mechanics. After adjusting for the 22% smaller muscle mass in old (73-89 years, n = 6) compared to young men (20-29 years, n = 6), isometric torque and power output of the knee extensors were, respectively, 38% and 53% lower with age. Fatigability was ∼2.7-fold greater with age and strongly associated with reductions in the electrically-evoked contractile properties. To test whether cross-bridge mechanisms could explain age-related decrements in knee extensor function, we exposed myofibres (n = 254) from the vastus lateralis to conditions mimicking quiescent muscle and fatiguing levels of acidosis (H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.