Evidence map›Paper›PMID 29806700›Full record

ArticleNeurourology and urodynamics2018

Targeting p75 neurotrophin receptors ameliorates spinal cord injury-induced detrusor sphincter dyssynergia in mice.

Irina V Zabbarova, Youko Ikeda, Evan J Carder, Peter Wipf, Amanda S Wolf-Johnston, Lori A Birder, Naoki Yoshimura, Samuel E Getchell, Khalifa Almansoori, Pradeep Tyagi and 3 more

Open access · greenAbstract read
In one paragraph

Article in Neurourology and urodynamics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Bladder p75Life (Basel, Switzerland) · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
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  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Irina V ZabbarovaDepartment of Medicine, University of Pittsburgh, Renal-Electrolyte Division, Pittsburgh, Pennsylvania.
Youko IkedaDepartment of Medicine, University of Pittsburgh, Renal-Electrolyte Division, Pittsburgh, Pennsylvania.
Evan J CarderDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Peter WipfDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Amanda S Wolf-JohnstonDepartment of Medicine, University of Pittsburgh, Renal-Electrolyte Division, Pittsburgh, Pennsylvania.
Lori A BirderDepartment of Medicine, University of Pittsburgh, Renal-Electrolyte Division, Pittsburgh, Pennsylvania.
Naoki YoshimuraDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0001-8070-1664
Samuel E GetchellDepartment of Medicine, University of Pittsburgh, Renal-Electrolyte Division, Pittsburgh, Pennsylvania.
Khalifa AlmansooriDepartment of Medicine, University of Pittsburgh, Renal-Electrolyte Division, Pittsburgh, Pennsylvania.
Pradeep TyagiDepartment of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Christopher H FrySchool of Physiology Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
Marcus J DrakeSchool of Physiology Pharmacology and Neuroscience, University of Bristol, Bristol, UK.ORCID 0000-0002-6230-2552
Anthony J KanaiDepartment of Medicine, University of Pittsburgh, Renal-Electrolyte Division, Pittsburgh, Pennsylvania.ORCID 0000-0003-4780-7592
University of Pittsburgh · USUniversity of Bristol · GB

Funding

Urothelium in Detrusor OveractivityP01DK093424 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEGROAT, WILLIAM C · 2013 to 2017
$7.9M
PDE5 Inhibition of Afferents and Interstitial Cells in Overactive Mouse BladdersR01DK098361 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRDER, LORI A, KANAI, ANTHONY JOHN · 2014 to 2024
$5.7M
Roles of Nitric Oxide and Superoxide in CystitisR01DK071085 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KANAI, ANTHONY JOHN · 2005 to 2017
$3.3M
Braithwaite FoundationNIDDK NIH HHS DK071085NIDDK NIH HHS P01 DK093424NIDDK NIH HHS R01 DK071085NIDDK NIH HHS R01 DK093424NIDDK NIH HHS R01 DK098361
6 · The paper itself

Abstract

aimsTo determine the role of p75 neurotrophin receptor (p75

methodsAdult female T

resultsOur studies confirm highest expression of p75

conclusionDrugs targeting p75

Indexed as

AnimalsElectromyographyIsoleucineLower Urinary Tract SymptomsMiceMorpholinesReceptor, Nerve Growth FactorSpinal Cord InjuriesUrethraUrinary Bladder DiseasesUrinary Bladder, OveractiveIsoleucineLM11A-31MorpholinesReceptor, Nerve Growth FactorLM11A-31lower urinary tract dysfunction/symptoms (LUTD/LUTS)neurodegenerationneurogenic bladder dysfunctionproneurotrophins

Identifiers

PMID29806700
PMCPMC6202156
OpenAlexW2806031118

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.