Evidence map›Paper›PMID 29806300›Full record

ArticleZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2018

[Effect of bone morphogenetic protein 7/poly (lactide-co-glycolide) microspheres on the

Jialei Chen, Ming Liu, Xin Duan, Fuguo Huang, Zhou Xiang

Open access · greenAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. [Research progress on controlled release of various growth factors in bone regeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2019
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jialei ChenDepartment of Orthopeadics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
Ming LiuDepartment of Orthopeadics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
Xin DuanDepartment of Orthopeadics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
Fuguo HuangDepartment of Orthopeadics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
Zhou XiangDepartment of Orthopeadics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.xiangzhou15@hotmail.com.
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the effect of bone morphogenetic protein 7 (BMP-7)/poly (lactide-co-glycolide) (PLGA) microspheres on Methods: BMP-7/PLGA microspheres were fabricated by double emulsion-drying in liquid method. After mixing BMP-7/PLGA microspheres with the chondrogenic differentiation medium, the supernatant was collected on the 1st, 3rd, 7th, 14th, and 21st day as the releasing solution. The BMSCs were isolated from the bilateral femurs and tibias of 3-5 days old New Zealand rabbits, and the 3rd generation BMSCs were divided into 2 groups: microspheres group and control group. The BMSCs in microspheres group were cultured by 200 μL BMP-7/PLGA microspheres releasing solution in the process of changing liquid every 2-3 days, while in control group were cultured by chondrogenic medium. The cell proliferation (by MTT assay) and the glycosaminoglycan (GAG) contents (by Alician blue staining) were detected after chondrogenic cultured for 1, 3, 7, 14, and 21 days. The chondrogenic differentiation of BMSCs was observed by safranine O staining, toluidine blue staining, and collagen type Ⅱ immunohistochemistry staining at 21 days. Results: MTT test showed that BMSCs proliferated rapidly in 2 groups at 1, 3, and 7 days; after 7 days, the proliferation of BMSCs in the control group was slow and the BMSCs in microspheres group continued to proliferate rapidly. There was no significant difference of the absorbance ( Conclusion: BMP-7/PLGA microspheres prepared by double emulsion-drying in liquid method

Indexed as

Bone Morphogenetic Protein 7Cell ProliferationMesenchymal Stem CellsMicrospheresTissue EngineeringAnimalsBone Marrow CellsCell DifferentiationCells, CulturedChondrogenesisCollagen Type IIDioxanesPolyestersRabbitsBMP7 protein, humanBone Morphogenetic Protein 7Collagen Type IIdilactideDioxanesPolyesterspoly(lactide)bone marrow mesenchymal stem cellsBone morphogenetic protein 7microspherespoly (lactide-co-glycolide)rabbit

Identifiers

PMID29806300
PMCPMC8414336
OpenAlexW3004229096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.