Evidence map›Paper›PMID 29806060›Full record

ArticleJournal of gastrointestinal cancer2019

Clinical Evaluation of Serum Tumor Markers in the Diagnosis of Gastric Adenocarcinoma Staging and Grading.

Bayazid Ghaderi, Hamoon Moghbel, Nasrin Daneshkhah, Asrin Babahajian, Farshad Sheikhesmaeili

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Bayazid GhaderiLiver and digestive research center, Kurdistan University of Medical Sciences, Sanandaj, Iran. bayazidg@yahoo.com.
Hamoon MoghbelLiver and digestive research center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Nasrin DaneshkhahInstructor Paramedical Faculty, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Asrin BabahajianLiver and digestive research center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Farshad SheikhesmaeiliLiver and digestive research center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Kurdistan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ᅟ: Detection and quantitative measurements of diffused tumor markers in blood samples of patients with cancer is a facile and convenient method to determine prognosis and the appropriateness of the treatment. This study was done to evaluate the level of CA125, CEA, AFP, Beta HCG, and CA19-9 tumor markers and their relation to the stage and grade of the disease in patients with gastric adenocarcinoma. MATERIALS AND

methodsIn a descriptive cross-sectional study, of 81 patients referred to the oncology department of Tohid Hospital, Sanandaj, Iran, in 1 year, with recently detected gastric adenocarcinoma, serum level of CEA, CA19-9, CA125, AFP, and Beta HCG tumor markers was measured by ELISA method before chemotherapy and surgery. Patients were divided into four groups based on stage of disease (I, II, III, IV), and in terms of tumor differentiation, degrees were classified in to three groups: low, high, and intermediate. To determine the correlation of tumor markers level with the stage and grade of the disease, the Kruskal-Wallis and Mann-Whitney U tests were used.

resultsBy progression, the stages of the disease, the serum level of CA19-9, CA125, and AFP tumor markers demonstrated a significant increase. But this difference between level of HCG and CEA was not significant with the staging. There was no significant difference between the serum level of tumor markers and the grading of disease in the patients.

conclusionPreoperative CA19-9, CA125, and AFP tumor markers measurements could be beneficial in detecting the progressed stages of the disease.

Indexed as

AdenocarcinomaAdultAgedAged, 80 and overalpha-FetoproteinsBiomarkers, TumorCA-125 AntigenCA-19-9 AntigenCarcinoembryonic AntigenChorionic Gonadotropin, beta Subunit, HumanCross-Sectional StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedAFP protein, humanalpha-FetoproteinsBiomarkers, TumorCA-125 AntigenCA-19-9 AntigenCarcinoembryonic AntigenChorionic Gonadotropin, beta Subunit, HumanAFPBeta HCGCA125CA19-9CEAGastric adenocarcinomaGradingStaging

Identifiers

PMID29806060
OpenAlexW2805907013

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.