ArticleIntensive care medicine2018
Transthoracic echocardiography and mortality in sepsis: analysis of the MIMIC-III database.
Article in Intensive care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
106 citing papers in PubMed, 1 synthesis or guideline pooled it, 251 citations in OpenAlex.
- Early management of adult sepsis and septic shock: Korean clinical practice guidelines.Acute and critical care · 2024Guideline
- Asymptomatic Hemorrhagic Events and Functional Outcomes in Acute Stroke: A Secondary Analysis of the DIRECT-MI Randomized Clinical Trial.JAMA network open · 2025Trial
- Effect of focused cardiopulmonary ultrasonography on clinical outcome of septic shock: a randomized study.The Journal of international medical research · 2021Trial
- Continual hemodynamic monitoring with a single-use transesophageal echocardiography probe in critically ill patients with shock: a randomized controlled clinical trial.Intensive care medicine · 2019Trial
- Neonatal sepsis and cardiovascular dysfunction II: assessment.Pediatric research · 2026Review
- Value of point-of-care ultrasound in the early identification of left ventricular dysfunction and prognostic assessment in cancer patients complicated by sepsis.Frontiers in oncology · 2026Article
- Confidence Interval Construction for Causally Generalized Estimates With Target Sample Summary Information.Statistics in medicine · 2026Article
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- From Fluid Responsiveness to Prognosis: The Emerging Role of Point-of-Care Echocardiography in Sepsis.Diagnostics (Basel, Switzerland) · 2025Review
- Delirium as a mediating factor in the survival benefits of dexmedetomidine in acute brain injury management.Scientific reports · 2025Article
- The association between the lactate to albumin ratio and all-cause mortality in cardiac arrest patients: an analysis of the MIMIC-IV database.European journal of medical research · 2025Article
- Point of care ultrasound for monitoring and resuscitation in patients with shock.Internal and emergency medicine · 2025Review
- Transthoracic echocardiography and mortality in sepsis-associated acute kidney injury: An analysis based on MIMC-IV database.Scientific reports · 2025Article
- 5-Hydroxymethylcytosine signatures as diagnostic biomarkers for septic cardiomyopathy.Scientific reports · 2025Article
- Prognostic value of dynamic KDIGO staging in acute kidney injury after acute heart failure: a doubly robust analysis.Scientific reports · 2025Article
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- Association between the (neutrophil + monocyte)/albumin ratio and all-cause mortality in sepsis patients: a retrospective cohort study and predictive model establishment according to machine learning.BMC infectious diseases · 2025Article
- Contribution of Open Access Databases to Intensive Care Medicine Research: Scoping Review.Journal of medical Internet research · 2025Article
- Sepsis-induced cardiogenic shock: controversies and evidence gaps in diagnosis and management.Journal of intensive care · 2025Review
46 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
purposeWhile the use of transthoracic echocardiography (TTE) in the ICU is rapidly expanding, the contribution of TTE to altering patient outcomes among ICU patients with sepsis has not been examined. This study was designed to examine the association of TTE with 28-day mortality specifically in that population. METHODS AND
resultsThe MIMIC-III database was employed to identify patients with sepsis who had and had not received TTE. The statistical approaches utilized included multivariate regression, propensity score analysis, doubly robust estimation, the gradient boosted model, and an inverse probability-weighting model to ensure the robustness of our findings. Significant benefit in terms of 28-day mortality was observed among the TTE patients compared to the control (no TTE) group (odds ratio = 0.78, 95% CI 0.68-0.90, p < 0.001). The amount of fluid administered (2.5 vs. 2.1 L on day 1, p < 0.001), use of dobutamine (2% vs. 1%, p = 0.007), and the maximum dose of norepinephrine (1.4 vs. 1 mg/min, p = 0.001) were significantly higher for the TTE patients. Importantly, the TTE patients were weaned off vasopressors more quickly than those in the no TTE group (vasopressor-free days on day 28 of 21 vs. 19, p = 0.004).
conclusionIn a general population of critically ill patients with sepsis, use of TTE is associated with an improvement in 28-day mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.