ArticleMedical & biological engineering & computing2018
Optimizing bone cement stiffness for vertebroplasty through biomechanical effects analysis based on patient-specific three-dimensional finite element modeling.
Article in Medical & biological engineering & computing, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Optimization of Bone Cement Stiffness in Metastatic Vertebral Augmentation: Balancing Strength Restoration and Stress Redistribution.Annals of biomedical engineering · 2026Article
- Biomechanical study of robot-navigated targeted cross-puncture percutaneous vertebroplasty for Kümmell's disease: finite element analysis.Frontiers in rehabilitation sciences · 2026Article
- Article
- Biomechanical comparison of different bilateral percutaneous vertebroplasty in treating osteoporotic vertebral compression fractures: finite element analysis.Frontiers in surgery · 2025Article
- Clinical efficacy and biomechanical analysis of a novel hollow pedicle screw combined with kyphoplasty for the treatment of Kümmell disease.JOR spine · 2024Article
- Image-Based Peridynamic Modeling-Based Micro-CT for Failure Simulation of Composites.Materials (Basel, Switzerland) · 2024Article
- Finite element analysis of precise puncture vertebral augmentation in the treatment of different types of osteoporotic vertebral compression fractures.BMC musculoskeletal disorders · 2024Article
- Preclinical Evaluation of Bioactive Small Intestinal Submucosa-PMMA Bone Cement for Vertebral Augmentation.ACS biomaterials science & engineering · 2024Article
- Article
- Enhancing percutaneous kyphoplasty efficacy in elderly osteoporotic fractures through optimal cement filling ratio.Frontiers in endocrinology · 2024Article
- Bone Cements Used in Vertebral Augmentation: A State-of-the-art Narrative Review.Journal of pain research · 2024Review
- Effect of cement volume on biomechanical response of a spine segment treated with a PEEK polymer implant: a finite element comparative study with vertebroplasty.Frontiers in bioengineering and biotechnology · 2024Article
- Finite element analysis of biomechanical effects of mineralized collagen modified bone cement on adjacent vertebral body after vertebroplasty.Frontiers in bioengineering and biotechnology · 2023Article
- Study of mechanical effects of lumbar disc arthroplasty on facet joints at the index level/adjacent levels by using a validated finite element analysis.Frontiers in bioengineering and biotechnology · 2023Article
- Biomechanical analysis of sandwich vertebrae in osteoporotic patients: finite element analysis.Frontiers in endocrinology · 2023Article
- A finite element analysis on different bone cement forms and injection volumes injected into lumbar vertebral body in percutaneous kyphoplasty.BMC musculoskeletal disorders · 2022Article
- A digital twin for simulating the vertebroplasty procedure and its impact on mechanical stability of vertebra in cancer patients.International journal for numerical methods in biomedical engineering · 2022Article
- A Three-Dimensional Cement Quantification Method for Decision Prediction of Vertebral Recompression after Vertebroplasty.Computational and mathematical methods in medicine · 2022Article
- Biomechanical comparison between unilateral and bilateral percutaneous vertebroplasty for osteoporotic vertebral compression fractures: A finite element analysis.Frontiers in bioengineering and biotechnology · 2022Article
- Influence of cement-augmented pedicle screw instrumentation in an osteoporotic lumbosacral spine over the adjacent segments: a 3D finite element study.Journal of orthopaedic surgery and research · 2020Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Vertebroplasty is a common and effective treatment for symptomatic osteoporotic vertebral compression fractures. However, the cemented and adjacent vertebras have a risk of recollapse due to largely unassured mechanisms, among which excessive stiffness of bone cement may be an important risk factor. This study aimed to find the most appropriate range of bone cement stiffness by analyzing its biomechanical effects on the augmented and adjacent vertebras of individual patient after vertebroplasty. A three-dimensional finite element model of T11-L1 osteoligamentous vertebras was reconstructed according to individual computed tomography data and validated by post mortem human subject experiment in literatures. Bone cement of varying stiffness was injected into the trabecular core of the T12 vertebra simulatively. The maximum von Mises stresses on cancellous and cortical bones of T11-L1 vertebras were analyzed under the loading conditions of flexion, extension, bending, and torsion. For the adjacent T11 and L1 vertebras, the stepwise elevation of the bone cement elastic modulus increased the maximum von Mises stress on the cancellous bone, but its effect on cortical bone was negligible. For the augmented T12 vertebra, the stresses on cancellous bone increased slightly under the loading condition of lateral bending and remained no impact on cortical bone. The linear interpolation revealed that the most suitable range of cement elastic modulus is 833.1 and 1408.1 Mpa for this patient. Increased elastic modulus of bone cement may lead to a growing risk of recollapse for the cemented vertebra as well as the adjacent vertebras. Our study provides a fresh perspective in clinical optimization of individual therapy in vertebroplasty. Graphical abstract ᅟ.
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