ArticleComputational toxicology (Amsterdam, Netherlands)2018
Performance of Machine Learning Algorithms for Qualitative and Quantitative Prediction Drug Blockade of hERG1 channel.
Article in Computational toxicology (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Extreme gradient boosting using conventional parameters accurately predicts insulin sensitivity in young and middle-aged Japanese persons.Frontiers in endocrinology · 2025Article
- Enhancing hERG Risk Assessment with Interpretable Classificatory and Regression Models.Chemical research in toxicology · 2024Article
- Derivation of Highly Predictive 3D-QSAR Models for hERG Channel Blockers Based on the Quantum Artificial Neural Network Algorithm.Pharmaceuticals (Basel, Switzerland) · 2023Article
- hERG Blockade Prediction by Combining Site Identification by Ligand Competitive Saturation and Physicochemical Properties.Chemistry (Basel, Switzerland) · 2022Article
- Graph-Based Feature Selection Approach for Molecular Activity Prediction.Journal of chemical information and modeling · 2022Article
- Arrhythmia Assessment in Heterotypic Human Cardiac Myocyte-Fibroblast Microtissues.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Article
- Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19.BMC pharmacology & toxicology · 2021Article
- Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach.Journal of chemical information and modeling · 2021Article
- A predictive in vitro risk assessment platform for pro-arrhythmic toxicity using human 3D cardiac microtissues.Scientific reports · 2021Article
- Machine Learning in Arrhythmia and Electrophysiology.Circulation research · 2021Review
- Bioactivity Comparison across Multiple Machine Learning Algorithms Using over 5000 Datasets for Drug Discovery.Molecular pharmaceutics · 2021Article
- Assessing hERG1 Blockade from Bayesian Machine-Learning-Optimized Site Identification by Ligand Competitive Saturation Simulations.Journal of chemical information and modeling · 2020Article
- Influence of feature rankers in the construction of molecular activity prediction models.Journal of computer-aided molecular design · 2020Article
- Allosteric Coupling Between Drug Binding and the Aromatic Cassette in the Pore Domain of the hERG1 Channel: Implications for a State-Dependent Blockade.Frontiers in pharmacology · 2020Article
- The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.Molecular pharmacology · 2019Article
- Capsule Networks Showed Excellent Performance in the Classification of hERG Blockers/Nonblockers.Frontiers in pharmacology · 2019Article
- Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities.Frontiers in pharmacology · 2018Article
- In silico toxicology: From structure-activity relationships towards deep learning and adverse outcome pathways.Wiley interdisciplinary reviews. Computational molecular scienceReview
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Drug-induced abnormal heart rhythm known as
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.