ArticleCardiology research and practice2018
Value of the New Spline QTc Formula in Adjusting for Pacing-Induced Changes in Heart Rate.
Article in Cardiology research and practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- QT Interval Evaluation in Right Ventricular Pacing: Validation of a Novel Formula.Pacing and clinical electrophysiology : PACE · 2026Article
- Concentration QTc analysis of giredestrant: Overcoming QT/heart rate confounding in the presence of drug-induced heart rate changes.Clinical and translational science · 2023Article
- The Short QTc Is a Marker for the Development of Atrial Flutter and Atrial Fibrillation.Cardiology research and practice · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine whether a new QTc calculation based on a Spline fit model derived and validated from a large population remained stable in the same individual across a range of heart rates (HRs). Second, to determine whether this formula incorporating QRS duration can be of value in QT measurement, compared to direct measurement of the JT interval, during ventricular pacing.
methodsIndividuals (
resultsThe new QTc changed minimally with shorter RR intervals, poorly fit even a linear relationship, and did not fit a second-order polynomial. In contrast, the Bazett formula (QTcBZT) showed a steep and marked increase in QTc with shorter RR intervals. For atrial pacing data, QTcBZT was fit best by a second-order polynomial and demonstrated a dramatic increase in QTc with progressively shorter RR intervals. For ventricular pacing, the new QTc minus QRS duration did not meaningfully change with HR in contrast to the HR dependency of QTcBZT and JT interval.
conclusionThe new QT correction formula is minimally impacted by HR acceleration induced by atrial or ventricular pacing. The Spline QTc minus QRS duration is an excellent method to estimate QTc in ventricular paced complexes.
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Registered trials
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