Evidence map›Paper›PMID 29805683›Full record

ArticleOncology letters2018

Screening therapeutic targets of ribavirin in hepatocellular carcinoma.

Chen Xu, Liyun Luo, Yongjun Yu, Zhao Zhang, Yi Zhang, Haimei Li, Yue Cheng, Hai Qin, Xipeng Zhang, Hongmei Ma and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. FBXO family genes promotes hepatocellular carcinoma via ubiquitination of p53.Journal of cancer research and clinical oncology · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. The role of Fbxo5 in the development of human malignant tumors.American journal of cancer research · 2022
    Review
  9. Article
  10. Anticancer Effects ofOncology research · 2019
    Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Chen XuDepartment of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, P.R. China.
Liyun LuoDepartment of Cardiology, The Fifth Affiliated Hospital of Sun Yan-Sen University, Zhuhai, Guangdong 519000, P.R. China.
Yongjun YuDepartment of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, P.R. China.
Zhao ZhangDepartment of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, P.R. China.
Yi ZhangDepartment of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, P.R. China.
Haimei LiDepartment of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, P.R. China.
Yue ChengDepartment of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, P.R. China.
Hai QinDepartment of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, P.R. China.
Xipeng ZhangDepartment of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, P.R. China.
Hongmei MaDepartment of Nursing, Tianjin Union Medical Center, Tianjin 300121, P.R. China.
Yuwei LiDepartment of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, P.R. China.
Tianjin People's Hospital · CNFifth Affiliated Hospital of Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of the present study was to screen the key genes of ribavirin in hepatocellular carcinoma (HCC) and provide novel therapeutic targets for HCC treatment. The mRNA expression datasets of GSE23031 and GSE74656, as well as the microRNA (miRNA) expression dataset of GSE22058 were downloaded from the Gene Expressed Omnibus database. In the GSE23031 dataset, there were three HCC cell lines treated with PBS and three HCC cell lines treated with ribavirin. In the GSE74656 dataset, five HCC tissues and five carcinoma adjacent tissues were selected. In the GSE22058 dataset, 96 HCC tissues and 96 carcinoma adjacent tissues were selected. The differentially expressed genes (DEGs) and differentially expressed miRNAs were identified via the limma package of

Indexed as

hepatocellular carcinomamicroarray analysisribavirin

Identifiers

PMID29805683
PMCPMC5958667
OpenAlexW2801940690

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.