Evidence map›Paper›PMID 29805583›Full record

ArticleOncology letters2018

Aberrant promoter methylation status is associated with upregulation of the E2F4 gene in breast cancer.

Farman Ullah Farman, Farhan Haq, Noor Muhammad, Nawab Ali, Hazir Rahman, Muhammad Saeed

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Large Yellow Croaker (International journal of molecular sciences · 2025
    Article
  3. Article
  4. Review
  5. Prognostic values ofBioscience reports · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Farman Ullah FarmanCancer Genetics and Epigenetics Laboratory, Department of Biosciences, COMSATS Institute of Information Technology, Chak Shahzad, Islamabad 45550, Pakistan.
Farhan HaqCancer Genetics and Epigenetics Laboratory, Department of Biosciences, COMSATS Institute of Information Technology, Chak Shahzad, Islamabad 45550, Pakistan.
Noor MuhammadDepartment of Biotechnology and Genetic Engineering, Kohat University of Science and Technology, Kohat 26000, Pakistan.
Nawab AliDepartment of Biotechnology and Genetic Engineering, Kohat University of Science and Technology, Kohat 26000, Pakistan.
Hazir RahmanDepartment of Microbiology, Abdul Wali Khan University Mardan, Khyber Pakhtunkhwa 23200, Pakistan.
Muhammad SaeedCancer Genetics and Epigenetics Laboratory, Department of Biosciences, COMSATS Institute of Information Technology, Chak Shahzad, Islamabad 45550, Pakistan.
COMSATS University Islamabad · PKKohat University of Science and Technology · PKAbdul Wali Khan University Mardan · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

E2F4 is an important basal transcription factor with the potential to promote tumor growth. Its upregulation in various types of cancer has been linked to numerous genetic factors; however, the nature of the involvement of epigenetic mechanisms, including DNA methylation, remains elusive. In the present study, E2F4 expression profiles were determined in 100 paired breast tumor and control samples, through RT-qPCR using the SYBR

Indexed as

breast neoplasmsE2F4 transcription factorMSPpromoter methylation

Identifiers

PMID29805583
PMCPMC5950537
OpenAlexW2794456415

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.