Evidence map›Paper›PMID 29805475›Full record

ArticleJournal of drug delivery science and technology2018

Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain.

Juan Sanchez-Ramos, Shijie Song, Xiaoyuan Kong, Parastou Foroutan, Gary Martinez, William Dominguez-Viqueria, Shyam Mohapatra, Subhra Mohapatra, Reka A Haraszti, Anastasia Khvorova and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of drug delivery science and technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 56 citations in OpenAlex.

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  9. Nucleic acid drug vectors for diagnosis and treatment of brain diseases.Signal transduction and targeted therapy · 2023
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  20. Kinetics ofJournal of drug delivery science and technology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Juan Sanchez-RamosDepartment of Neurology, University of South Florida, Tampa, FL, USA.
Shijie SongDepartment of Neurology, University of South Florida, Tampa, FL, USA.
Xiaoyuan KongDepartment of Neurology, University of South Florida, Tampa, FL, USA.
Parastou ForoutanMofftt Cancer Center and Research Institute, Tampa, FL, USA.
Gary MartinezMofftt Cancer Center and Research Institute, Tampa, FL, USA.
William Dominguez-ViqueriaMofftt Cancer Center and Research Institute, Tampa, FL, USA.
Shyam MohapatraNanomedicine Research Center, Tampa, FL, USA.
Subhra MohapatraDepartment of Molecular Medicine, Tampa, FL, USA.
Reka A HarasztiRNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
Anastasia KhvorovaRNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
Neil AroninDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Vasyl SavaDepartment of Neurology, University of South Florida, Tampa, FL, USA.
University of South Florida · USMoffitt Cancer Center · USUniversity of Massachusetts Chan Medical School · USUniversity of Tampa · US

Funding

Nanocarriers Designed to Deliver Nucleic Acids to BrainR01NS095563 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI SANCHEZ-RAMOS, JUAN R · 2015 to 2019
$2.0M
Mid-Scale RNA Synthesis, Purification and Quality Control SystemS10OD020012 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KHVOROVA, ANASTASIA · 2015 to 2015
$563k
BLRD VA I01 BX004037NIH HHS S10 OD020012NINDS NIH HHS R01 NS095563
6 · The paper itself

Abstract

The overall objective of the present research was to develop a nanocarrier system for non-invasive delivery to brain of molecules useful for gene therapy. Manganese-containing nanoparticles (mNPs) carrying

Indexed as

Gene silencingIntranasal routeNanocarrierSmall animal MRI

Identifiers

PMID29805475
PMCPMC5967853
OpenAlexW2768540019

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.