ArticleInternational journal of biomedical imaging2018
Cryo-Imaging and Software Platform for Analysis of Molecular MR Imaging of Micrometastases.
Article in International journal of biomedical imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Optimal slice thickness for improved accuracy of quantitative analysis of fluorescent cell and microsphere distribution in cryo-images.Scientific reports · 2023Article
- Spleen Tissue Segmentation Algorithm for Cryo-Imaging Data.Journal of digital imaging · 2023Article
- Deep learning multi-organ segmentation for whole mouse cryo-images including a comparison of 2D and 3D deep networks.Scientific reports · 2022Article
- Quantitative analysis of metastatic breast cancer in mice using deep learning on cryo-image data.Scientific reports · 2021Article
- A hyperspectral approach for recovering agent excretion biodistributions using whole-body fluorescence cryo-imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2021Article
- Hyperspectral imaging and spectral unmixing for improving whole-body fluorescence cryo-imaging.Biomedical optics express · 2021Article
- Diversity in cancer invasion phenotypes indicates specific stroma regulated programs.Human cell · 2021Article
- A practical method for multimodal registration and assessment of whole-brain disease burden using PET, MRI, and optical imaging.Scientific reports · 2020Article
- Systems Biology of Cancer Metastasis.Cell systems · 2019Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
We created and evaluated a preclinical, multimodality imaging, and software platform to assess molecular imaging of small metastases. This included experimental methods (e.g., GFP-labeled tumor and high resolution multispectral cryo-imaging), nonrigid image registration, and interactive visualization of imaging agent targeting. We describe technological details earlier applied to GFP-labeled metastatic tumor targeting by molecular MR (CREKA-Gd) and red fluorescent (CREKA-Cy5) imaging agents. Optimized nonrigid cryo-MRI registration enabled nonambiguous association of MR signals to GFP tumors. Interactive visualization of out-of-RAM volumetric image data allowed one to zoom to a GFP-labeled micrometastasis, determine its anatomical location from color cryo-images, and establish the presence/absence of targeted CREKA-Gd and CREKA-Cy5. In a mouse with >160 GFP-labeled tumors, we determined that in the MR images every tumor in the lung >0.3 mm
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.