Evidence map›Paper›PMID 29805311›Full record

ArticleMediators of inflammation2018

Selenoprotein S Attenuates Tumor Necrosis Factor-

Siyuan Cui, Lili Men, Yu Li, Yingshuo Zhong, Shanshan Yu, Fang Li, Jianling Du

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Review
  7. "Alphabet" Selenoproteins: Their Characteristics and Physiological Roles.International journal of molecular sciences · 2023
    Review
  8. Review
  9. Selenoprotein S: A versatile disordered protein.Archives of biochemistry and biophysics · 2022
    Review
  10. Review
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Siyuan CuiDepartment of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China.
Lili MenDepartment of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China.
Yu LiDepartment of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China.
Yingshuo ZhongDepartment of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China.
Shanshan YuDepartment of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China.
Fang LiDepartment of Immunology, Dalian Medical University, Dalian, Liaoning 116044, China.ORCID 0000-0003-4402-2386
Jianling DuDepartment of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China.ORCID 0000-0001-9042-6969
Dalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelial dysfunction, partly induced by inflammatory mediators, is known to initiate and promote several cardiovascular diseases. Selenoprotein S (SelS) has been identified in endothelial cells and is associated with inflammation; however, its function in inflammation-induced endothelial dysfunction has not been described. We first demonstrated that the upregulation of SelS enhances the levels of nitric oxide and endothelial nitric oxide synthase in tumor necrosis factor- (TNF-)

Indexed as

AnimalsBlotting, WesternCell AdhesionCell LineCell SurvivalDiet, High-FatEnzyme-Linked Immunosorbent AssayHumansHuman Umbilical Vein Endothelial CellsImmunohistochemistryMaleMiceMice, KnockoutNitric OxideSelenoproteinsTumor Necrosis Factor-alphaNitric OxideSelenoproteinsTumor Necrosis Factor-alpha

Identifiers

PMID29805311
PMCPMC5901950
OpenAlexW2795163990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.