ArticleInternational journal of biological sciences2018
PM2.5 induces autophagy-mediated cell death via NOS2 signaling in human bronchial epithelium cells.
Article in International journal of biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Environmental risk factors, protective factors and lifestyles for lung cancer: an umbrella review.Frontiers in public health · 2025Pooled it
- Mitigating PM2.5-induced skin injury and aging: botanical strategies targeting redox and inflammatory pathways.Redox report : communications in free radical research · 2026Review
- Health Risk and Pathogenesis of PMToxics · 2026Review
- PM2.5 as a driver of human health disorders: insights from the regulated cell death pathways.Military Medical Research · 2026Review
- Mass spectrometry analysis of PMAnalytical and bioanalytical chemistry · 2025Article
- Aurantio-Obtusin Suppresses Airway Inflammation and Serum ICAM-1 Expression in Guinea Pig Allergic Asthma Model.Immunity, inflammation and disease · 2025Article
- Epidemiological association and machine learning-based prediction of lung cancer risk linked to long-term lagged satellite-derived PMFrontiers in public health · 2025Article
- Long-term associations of PMERJ open research · 2024Article
- Unveiling the potent effect of vitamin D: harnessing Nrf2/HO-1 signaling pathways as molecular targets to alleviate urban particulate matter-induced asthma inflammation.BMC pulmonary medicine · 2024Article
- Endoplasmic reticulum stress: a vital process and potential therapeutic target in chronic obstructive pulmonary disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Review
- Cell Death Pathways: The Variable Mechanisms Underlying Fine Particulate Matter-Induced Cytotoxicity.ACS nanoscience Au · 2023Review
- A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence.Particle and fibre toxicology · 2022Review
- Alveolar Type II Cell Damage and Nrf2-SOD1 Pathway Downregulation Are Involved in PMInternational journal of environmental research and public health · 2022Article
- Air Pollution Health Impact Monitoring and Health Risk Assessment Technology and Its Application - China, 2006-2019.China CDC weekly · 2022Review
- Recent Insights into Particulate Matter (PMInternational journal of environmental research and public health · 2022Review
- The relationship of polluted air and drinking water sources with the prevalence of systemic lupus erythematosus: a provincial population-based study.Scientific reports · 2021Article
- Budesonide repairs decreased barrier integrity of eosinophilic nasal polyp epithelial cells caused by PMClinical and translational allergy · 2021Article
- Autophagy attenuates particulate matter 2.5-induced damage in HaCaT cells.Annals of translational medicine · 2021Article
- Fine particulate matter induces airway inflammation by disturbing the balance between Th1/Th2 and regulation of GATA3 and Runx3 expression in BALB/c mice.Molecular medicine reports · 2021Article
- Micro- and Nanosized Substances Cause Different Autophagy-Related Responses.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biggest victim of ambient air pollution is the respiratory system. Mainly because of the harmful components, especially the particulate matters with an aerodynamic diameter of ≤ 2.5µm (PM2.5), can be directly inhaled and deeply penetrate into the lung alveoli, thus causing severe lung dysfunction, including chronic cough, bronchitis and asthma, even lung cancer. Unfortunately, the toxicological mechanisms of PM2.5 associations with these adverse respiratory outcomes have still not been clearly unveiled. Here, we found that PM2.5 rapidly induced inflammatory responses, oxidative injure and cell death in human bronchial epithelium cells through upregulation of IL-6 expression, ROS production and apoptosis. Furthermore, PM2.5 specifically induced nitric oxide synthase 2 (NOS2) expression and NO generation to elevate excessive autophagy. Finally, disruption of NOS2 signaling effectively blocked autophayosome formation and the subsequent cell death. Our novel findings systemically reveled the role of autophagy-mediated cell death in PM2.5-treated human bronchial epithelium cells and provided potential strategy for future clinic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.