ArticleCell host & microbe2018
Genomic Epidemiology Reconstructs the Introduction and Spread of Zika Virus in Central America and Mexico.
Article in Cell host & microbe, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and evaluation of Zika virus forecasting and prediction research during a public health emergency of international concern.PLoS neglected tropical diseases · 2019Pooled it
- Acute Zika virus infection in an asymptomatic blood donor at the onset of the Puerto Rico epidemic.Transfusion · 2019Trial
- Circulation of chikungunya virus East/Central/South African lineage in Rio de Janeiro, Brazil.PloS one · 2019Trial
- A highly sensitive amplicon sequencing workflow for genomic surveillance of Usutu virus.Virology journal · 2026Article
- Unveiling the global urban virome through wastewater metagenomics.Nature communications · 2025Article
- Reliable estimates of Japanese encephalitis virus evolutionary rate supported by a formal test of temporal signal.Molecular genetics and genomics : MGG · 2025Article
- The Zika virus NS5 protein binds HSP90 to suppress EGF-induced Akt signaling and trophoblast cell migration.Virology · 2025Article
- Article
- Hybrid-Capture Target Enrichment in Human Pathogens: Identification, Evolution, Biosurveillance, and Genomic Epidemiology.Pathogens (Basel, Switzerland) · 2024Review
- Synchrony of Bird Migration with Global Dispersal of Avian Influenza Reveals Exposed Bird Orders.Nature communications · 2024Article
- Epidemiological, virological and clinical characterization of a Dengue/Zika outbreak in the Caribbean region of Costa Rica 2017-2018.Frontiers in cellular and infection microbiology · 2024Article
- Empowering public health: building advanced molecular surveillance in resource-limited settings through collaboration and capacity-building.Frontiers in health services · 2024Article
- Convergent trends and spatiotemporal patterns of Aedes-borne arboviruses in Mexico and Central America.PLoS neglected tropical diseases · 2023Article
- Comparing the evolutionary dynamics of predominant SARS-CoV-2 virus lineages co-circulating in Mexico.eLife · 2023Article
- Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil.Nature communications · 2023Article
- Increased interregional virus exchange and nucleotide diversity outline the expansion of the chikungunya virus ECSA lineage in Brazil.medRxiv : the preprint server for health sciences · 2023Article
- Repeated Rapid Active Sampling Surveys Demonstrated a Rapidly Changing Zika Seroprevalence among Children in a Rural Dengue-endemic Region in Southwest Guatemala during the Zika Epidemic (2015-2016).The American journal of tropical medicine and hygiene · 2022Article
- Next Generation and Other Sequencing Technologies in Diagnostic Microbiology and Infectious Diseases.Genes · 2022Review
- A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil.Microbiology spectrum · 2022Article
- West Nile virus transmission potential in Portugal.Communications biology · 2022Article
Corrections and comments
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Authors and funding
29 authors.
Funding
Abstract
The Zika virus (ZIKV) epidemic in the Americas established ZIKV as a major public health threat and uncovered its association with severe diseases, including microcephaly. However, genetic epidemiology in some at-risk regions, particularly Central America and Mexico, remains limited. We report 61 ZIKV genomes from this region, generated using metagenomic sequencing with ZIKV-specific enrichment, and combine phylogenetic, epidemiological, and environmental data to reconstruct ZIKV transmission. These analyses revealed multiple independent ZIKV introductions to Central America and Mexico. One introduction, likely from Brazil via Honduras, led to most infections and the undetected spread of ZIKV through the region from late 2014. Multiple lines of evidence indicate biannual peaks of ZIKV transmission in the region, likely driven by varying local environmental conditions for mosquito vectors and herd immunity. The spatial and temporal heterogeneity of ZIKV transmission in Central America and Mexico challenges arbovirus surveillance and disease control measures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.