Evidence map›Paper›PMID 29805077›Full record

ArticleCancer cell2018

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance.

Nobuaki Takahashi, Hsing-Yu Chen, Isaac S Harris, Daniel G Stover, Laura M Selfors, Roderick T Bronson, Thomas Deraedt, Karen Cichowski, Alana L Welm, Yasuo Mori and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed, 2 pooled it
15.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 2 syntheses or guidelines pooled it, 273 citations in OpenAlex.

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  15. Metabolic starvation-induced cell swelling drives solid stress in tumors.bioRxiv : the preprint server for biology · 2026
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102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Nobuaki TakahashiDepartment of Cell Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA.
Hsing-Yu ChenDepartment of Cell Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA.
Isaac S HarrisDepartment of Cell Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA.
Daniel G StoverDepartment of Cell Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Laura M SelforsDepartment of Cell Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA.
Roderick T BronsonRodent Histopathology Core, Harvard Medical School, Boston, MA 02115, USA.
Thomas DeraedtDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Karen CichowskiDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Alana L WelmDepartment of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.
Yasuo MoriDepartment of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
Gordon B MillsDepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Joan S BruggeDepartment of Cell Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA. Electronic address: joan_brugge@hms.harvard.edu.
Harvard University · USBrigham and Women's Hospital · USDana-Farber Cancer Institute · USKyoto University · JPThe University of Texas MD Anderson Cancer Center · USUniversity of Utah · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Elucidating the Regulation and Function of the NF1 tumor suppressorR01CA111754 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI KAREN M CICHOWSKI · 2005 to 2026
$7.4M
NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA111754
6 · The paper itself

Abstract

Cancer cell survival is dependent on oxidative-stress defenses against reactive oxygen species (ROS) that accumulate during tumorigenesis. Here, we show a non-canonical oxidative-stress defense mechanism through TRPA1, a neuronal redox-sensing Ca

Indexed as

A549 CellsAdaptation, PhysiologicalAnimalsCell LineCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMice, Inbred NODMice, KnockoutMice, SCIDNeoplasmsNeuronsNF-E2-Related Factor 2Oxidation-ReductionOxidative StressNFE2L2 protein, humanNF-E2-Related Factor 2TRPA1 Cation Channelanchorage-independent growthanti-apoptosisCa(2+) signalingchemotherapy resistanceNRF2oxidative stressTRPA1TRP channeltumor progression

Identifiers

PMID29805077
PMCPMC6100788
OpenAlexW2804011812

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.