ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2019
Working Memory Load and Negative Picture Processing: Neural and Behavioral Associations With Panic, Social Anxiety, and Positive Affect.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuroimaging insights into the psychosocial impact of the COVID-19 pandemic: a systematic review.Translational psychiatry · 2025Pooled it
- Positive emotion up-regulation is resistant to working memory load: An electrocortical investigation of reappraisal and savoring.Psychophysiology · 2023Trial
- Neural mechanisms and predictors of SSRI and CBT treatment of anxiety: A randomized trial focused on emotion and cognitive processing.Journal of anxiety disorders · 2021Trial
- Working Memory Load Reduces the Electrocortical Processing of Negative Pictures but Accentuates Their Processing at Subsequent Viewing.Psychophysiology · 2026Article
- Memory in Psychiatric Disorders: A Review.Life (Basel, Switzerland) · 2025Review
- Anxiety Sensitivity and Intolerance of Uncertainty Uniquely Explain the Association of the Late Positive Potential With Generalized Anxiety Disorder Symptoms.Psychophysiology · 2025Article
- Engagement and Disengagement: From the Basic Science of Emotion Regulation to an Anxiety Spectrum.Psychophysiology · 2025Review
- Intact but vulnerable: Affective working memory in social anxiety disorder.PLOS mental health · 2025Review
- Error monitoring under working memory load: An electrocortical investigation.Psychophysiology · 2024Article
- Biological sex and hormonal contraceptive associations with drug cue reactivity in cannabis use disorder.Journal of psychiatric research · 2024Article
- The "psychiatric" neuron: the psychic neuron of the cerebral cortex, revisited.Frontiers in human neuroscience · 2024Review
- Autism Traits and Cognitive Performance: Mediating Roles of Sleep Disturbance, Anxiety and Depression.Journal of autism and developmental disorders · 2023Article
- Behavioral and ERP indices of self-schematic processing show differential associations with emerging symptoms of depression and social anxiety in late childhood: Evidence from a community-dwelling sample.Biological psychology · 2023Article
- Neural reactivity to affective stimuli and internalizing symptom dimensions in a transdiagnostic patient sample.Depression and anxiety · 2022Article
- The late positive potential during affective picture processing: Associations with daily life emotional functioning among adolescents with anxiety disorders.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2022Article
- Aging and distractor resistance in working memory: Does emotional valence matter?BMC psychology · 2022Article
- Event-related potential studies of emotion regulation: A review of recent progress and future directions.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2022Review
- Emotional processing prospectively modulates the impact of anxiety on COVID-19 pandemic-related post-traumatic stress symptoms: an ERP study.Journal of affective disorders · 2022Article
- Modulation of threat extinction by working memory load: An event-related potential study.Behaviour research and therapy · 2022Article
- The neural correlates of interference control dysfunction of working memory in major depressive disorder: An event-related potential study.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundInternalizing disorders such as anxiety may be characterized by an imbalance between bottom-up (stimulus-driven) and top-down (goal-directed) attention. The late positive potential (LPP) can be used to assess these processes when task-irrelevant negative and neutral pictures are presented within a working memory paradigm. Prior work using this paradigm has found that working memory load reduces the picture-elicited LPP across participants; however, anxious individuals showed a reduced effect of working memory load on the LPP, suggesting increased distractibility.
methodsThe current study assessed transdiagnostic associations between specific symptom dimensions of anxiety, the LPP, and behavior in a clinically representative, heterogeneous group of 76 treatment-seeking patients with internalizing disorders, who performed a working memory task interspersed with negative and neutral pictures.
resultsAs expected, negative pictures enhanced the LPP, and working memory load reduced the LPP. Participants with higher social anxiety showed increased LPPs to negative stimuli during early and late portions of picture presentation. Panic symptoms were associated with reduced LPPs to negative pictures compared with neutral pictures as well as a reduced effect of working memory load on the LPP during the late time window. Reduced positive affect was associated with greater behavioral interference from negative pictures.
conclusionsHypervigilance for negative stimuli was uniquely explained by social anxiety symptoms, whereas panic symptoms were associated with the opposing effect-blunted processing/avoidance of these stimuli. Panic symptoms were uniquely associated with reduced top-down control. Results reveal distinct associations between neural reactivity and anxiety symptom dimensions that transcend traditional diagnostic boundaries.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.