ArticleCell stem cell2018
Exit from Naive Pluripotency Induces a Transient X Chromosome Inactivation-like State in Males.
Article in Cell stem cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus.Nature structural & molecular biology · 2025Article
- The interferon γ pathway enhances pluripotency and X-chromosome reactivation in iPSC reprogramming.Science advances · 2024Article
- Establishment and maintenance of random monoallelic expression.Development (Cambridge, England) · 2024Review
- Hallmarks of totipotent and pluripotent stem cell states.Cell stem cell · 2024Review
- Review
- Regulatory principles and mechanisms governing the onset of random X-chromosome inactivation.Current opinion in genetics & development · 2023Review
- Three-dimensional genome structure and function.MedComm · 2023Review
- Species-specific regulation of XIST by the JPX/FTX orthologs.Nucleic acids research · 2023Article
- A NovelMolecular and cellular biology · 2021Article
- Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution.Nature communications · 2021Article
- Sox2 modulation increases naïve pluripotency plasticity.iScience · 2021Article
- Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency.Cell stem cell · 2021Article
- X-Chromosome Inactivation and Autosomal Random Monoallelic Expression as "Faux Amis".Frontiers in cell and developmental biology · 2021Review
- Review
- Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation.Nature cell biology · 2020Article
- Stirred suspension bioreactors maintain naïve pluripotency of human pluripotent stem cells.Communications biology · 2020Article
- Article
- A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary.Molecular cell · 2020Article
- RNA-seq as a tool for evaluating human embryo competence.Genome research · 2019Article
- Dynamic reversal of random X-Chromosome inactivation during iPSC reprogramming.Genome research · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
A hallmark of naive pluripotency is the presence of two active X chromosomes in females. It is not clear whether prevention of X chromosome inactivation (XCI) is mediated by gene networks that preserve the naive state. Here, we show that robust naive pluripotent stem cell (nPSC) self-renewal represses expression of Xist, the master regulator of XCI. We found that nPSCs accumulate Xist on the male X chromosome and on both female X chromosomes as they become NANOG negative at the onset of differentiation. This is accompanied by the appearance of a repressive chromatin signature and partial X-linked gene silencing, suggesting a transient and rapid XCI-like state in male nPSCs. In the embryo, Xist is transiently expressed in males and in females from both X chromosomes at the onset of naive epiblast differentiation. In conclusion, we propose that XCI initiation is gender independent and triggered by destabilization of naive identity, suggesting that gender-specific mechanisms follow, rather than precede, XCI initiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.