Evidence map›Paper›PMID 29804833›Full record

ArticleCell2018

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.

Christine A Olson, Helen E Vuong, Jessica M Yano, Qingxing Y Liang, David J Nusbaum, Elaine Y Hsiao

Erratum issued 3 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 538 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
538citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05219006 nacompletednot on this mapstarted 2021, after this paper: background citation

Ketogenic Diet Effects on the Frequency of Non Epileptic Seizures in Patients With Dissociative Neurological Symptom Disorder: a Pilot Study

TypeinterventionalSponsorEl Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco SuarezRan2021 to 2023Enrolled17ConditionsNon Epileptic Seizures, Functional Neurological Symptom Disorder, Conversion Disorder, Ketogenic DietingArmsketogenic dieting, healthy dieting
NCT05469997 nacompletednot on this mapstarted 2023, after this paper: background citation

Ketogenic Diet Interventions in Parkinson's Disease: Safeguarding the Gut Microbiome

TypeinterventionalSponsorUniversity of British ColumbiaRan2023 to 2024Enrolled52ConditionsParkinson DiseaseArmsMediterranean-Ketogenic Diet, Mediterranean diet supplemented with medium-chain triglyceride oil
NCT05898438 unknown statusnot on this mapstarted 2019, after this paper: background citation

The Role of Gut Microbiota in Children With Epilepsy Following Ketogenic Diet

TypeobservationalSponsorAttikon HospitalRan2019 to 2024Enrolled20ConditionsEpilepsy
3 · Its place in the literature

Who cites it

538 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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478 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Christine A OlsonDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Helen E VuongDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jessica M YanoDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Qingxing Y LiangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
David J NusbaumDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Elaine Y HsiaoDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: ehsiao@ucla.edu.

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TACHE, YVETTE FRANCE · 1990 to 2019
$18.0M
GASTROENTEROLOGYT32DK007180 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JENSEN, DENNIS MICHAEL · 1986 to 2025
$10.0M
UPLIFT: UCLA Postdocs' Longitudinal Investment in Faculty TrainingK12GM106996 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAREY, MICHAEL F, VILLANUEVA, CLAUDIO J · 2016 to 2025
$7.1M
Training in Molecular, Cellular &Integrative PhysiologyT32GM065823 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIDBALL, JAMES G · 2003 to 2017
$2.1M
Uncovering microbial modulators of neuroactive molecules as novel therapeutics.DP5OD017924 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAO, ELAINE · 2013 to 2017
$1.9M
Functional Role of IL-6 in Fetal Brain Development and Abnormal BehaviorF31MH090749 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI HSIAO, ELAINE · 2011 to 2012
$64k
NIDDK NIH HHS P30 DK041301NIDDK NIH HHS T32 DK007180NIGMS NIH HHS K12 GM106996NIGMS NIH HHS T32 GM065823NIH HHS DP5 OD017924NIMH NIH HHS F31 MH090749
6 · The paper itself

Abstract

The ketogenic diet (KD) is used to treat refractory epilepsy, but the mechanisms underlying its neuroprotective effects remain unclear. Here, we show that the gut microbiota is altered by the KD and required for protection against acute electrically induced seizures and spontaneous tonic-clonic seizures in two mouse models. Mice treated with antibiotics or reared germ free are resistant to KD-mediated seizure protection. Enrichment of, and gnotobiotic co-colonization with, KD-associated Akkermansia and Parabacteroides restores seizure protection. Moreover, transplantation of the KD gut microbiota and treatment with Akkermansia and Parabacteroides each confer seizure protection to mice fed a control diet. Alterations in colonic lumenal, serum, and hippocampal metabolomic profiles correlate with seizure protection, including reductions in systemic gamma-glutamylated amino acids and elevated hippocampal GABA/glutamate levels. Bacterial cross-feeding decreases gamma-glutamyltranspeptidase activity, and inhibiting gamma-glutamylation promotes seizure protection in vivo. Overall, this study reveals that the gut microbiota modulates host metabolism and seizure susceptibility in mice.

Indexed as

Diet, KetogenicGastrointestinal MicrobiomeAnimalsAnti-Bacterial AgentsBacteroidesDisease Models, AnimalFecesgamma-Aminobutyric Acidgamma-GlutamyltransferaseGlutamic AcidHippocampusIntestinal MucosaKv1.1 Potassium ChannelMetabolomeMiceMice, Inbred C3HAnti-Bacterial Agentsgamma-Aminobutyric Acidgamma-GlutamyltransferaseGlutamic AcidKcna1 protein, mouseKv1.1 Potassium ChannelRNA, Ribosomal, 16S6-Hz seizuresAkkermansiaepilepsygamma-glutamyl transpeptidaseGGsTopKcna1ketogenic dietmicrobiomemicrobiotaParabacteroides

Identifiers

PMID29804833
PMCPMC6003870

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.