Evidence map›Paper›PMID 29804820›Full record

ArticleStructure (London, England : 1993)2018

Mis16 Switches Function from a Histone H4 Chaperone to a CENP-A

Sojin An, Philipp Koldewey, Jennifer Chik, Lakxmi Subramanian, Uhn-Soo Cho

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Structure (London, England : 1993), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Epigenetic regulation of centromere function.Cellular and molecular life sciences : CMLS · 2020
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Sojin AnDepartment of Biological Chemistry, University of Michigan Medical School, 1150 W. Medical Center Drive, SPC 5606, Ann Arbor, MI 48109, USA.
Philipp KoldeweyDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Jennifer ChikDepartment of Biological Chemistry, University of Michigan Medical School, 1150 W. Medical Center Drive, SPC 5606, Ann Arbor, MI 48109, USA; Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Lakxmi SubramanianSchool of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, UK.
Uhn-Soo ChoDepartment of Biological Chemistry, University of Michigan Medical School, 1150 W. Medical Center Drive, SPC 5606, Ann Arbor, MI 48109, USA; Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: uhnsoo@med.umich.edu.
University of Michigan–Ann Arbor · USQueen Mary University of London · GB

Funding

CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
The molecular mechanisms of nutrient- and stress-dependent mTORC1 regulation mediated by human Sestrin2.R01DK111465 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHO, UHN-SOO · 2016 to 2020
$2.4M
Structure-based biochemical understanding of Sestrins in aging and metabolismR21AG050903 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHO, UHN-SOO, LEE, JUN HEE · 2015 to 2016
$426k
Biotechnology and Biological Sciences Research Council BB/R00868X/1Howard Hughes Medical InstituteNIA NIH HHS R21 AG050903NIDDK NIH HHS R01 DK111465NIGMS NIH HHS T32 GM007315
6 · The paper itself

Abstract

The Mis18 complex, composed of Mis16, Eic1, and Mis18 in fission yeast, selectively deposits the centromere-specific histone H3 variant, CENP-A

Indexed as

Carrier ProteinsChromosomal Proteins, Non-HistoneCrystallography, X-RayHistonesModels, MolecularMultiprotein ComplexesProtein MultimerizationSchizosaccharomycesSchizosaccharomyces pombe ProteinsCarrier ProteinsChromosomal Proteins, Non-HistoneCnp1 protein, S pombeHistonesMis16 protein, S pombeMis18 protein, S pombeMis19 protein, S pombeMultiprotein ComplexesSchizosaccharomyces pombe Proteinsanalytical ultracentrifugationCENP-AcentromereEic1fission yeasthistone chaperonekinetochoreMis16the Mis18 holo-complexX-ray crystallography

Identifiers

PMID29804820
PMCPMC6031460
OpenAlexW2804902596

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.