Evidence map›Paper›PMID 29804669›Full record

ArticleMethods in cell biology2018

Measuring mitotic forces.

Anna A Ye, Thomas J Maresca

Open access · greenAbstract read
In one paragraph

Article in Methods in cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anna A YeBiology Department, University of Massachusetts, Amherst, MA, United States; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, United States.
Thomas J MarescaBiology Department, University of Massachusetts, Amherst, MA, United States; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, United States. Electronic address: tmaresca@bio.umass.edu.
University of Massachusetts Amherst · US

Funding

Mechano-molecular regulation of kinetochore functionR01GM107026 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MARESCA, THOMAS JOSEPH · 2013 to 2022
$2.7M
NIGMS NIH HHS R01 GM107026
6 · The paper itself

Abstract

Productive chromosome movements require that a large multiprotein complex called the kinetochore assemble on sister centromeres. The kinetochore fulfills two critical functions as (1) the physical linkage between chromosomes and spindle microtubules and (2) a mechanomolecular sensor that relays a spindle assembly checkpoint signal delaying anaphase onset until chromosomes are attached to spindle microtubules and bioriented. Given its central roles in such a vital process, the kinetochore is one of the most important force-transducing structures in cells; yet it has been technically challenging to measure kinetochore forces. Barriers to measuring cellular forces have begun to be broken by the development of fluorescence-based tension sensors. In this chapter, two methods will be described for measuring kinetochore forces in living cells and strategies for applying these sensors to other force-transducing processes and molecules will be discussed.

Indexed as

MitosisAnimalsBiomechanical PhenomenaBiosensing TechniquesCytological TechniquesDrosophilaFluorescence Resonance Energy TransferPhotobleachingTalinVinculinTalinVinculinForceKinetochoreMeiosisMicrotubulesMitosisTension

Identifiers

PMID29804669
PMCPMC7286078
OpenAlexW2796913254

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.