ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2018
Interferon-γ and CXCL10 responses related to complaints in patients with Q fever fatigue syndrome.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 29 citations in OpenAlex.
- Health-related quality of life changes in patients with Q-fever fatigue syndrome: a four-year follow-up study, 10 years post-infection.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Observational
- Role of Trained Immunity in Heath and Disease.Current cardiology reports · 2025Review
- Bulk RNA sequencing for analysis of post COVID-19 condition in adolescents and young adults.Journal of translational medicine · 2024Article
- Article
- Cytometry profiling ofFrontiers in immunology · 2023Article
- Multi-omics examination of Q fever fatigue syndrome identifies similarities with chronic fatigue syndrome.Journal of translational medicine · 2020Article
- Long-Lasting Transcriptional Changes in Circulating Monocytes of Acute Q Fever Patients.Open forum infectious diseases · 2019Article
- A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome.Journal of translational medicine · 2019Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Approximately 20% of patients with acute Q fever develop Q fever fatigue syndrome (QFS), a debilitating fatigue syndrome. This study further investigates the role of C. burnetii-specific IFNγ, but also IL-2, CXCL9, CXCL10, and CXLC11 production in QFS patients. C. burnetii-specific IFNy, IL-2, CXCL9, CXCL10, and CXCL11 production were tested in ex vivo stimulated whole blood of QFS patients who recovered from their complaints (n = 8), QFS patients with persisting complaints (n = 27), and asymptomatic Q fever seropositive controls (n = 10). With the exclusion of one outlier, stimulation with C. burnetii revealed significantly higher IFNy and CXCL10 production in QFS patients with persisting complaints (medians 288.0 and 176.0 pg/mL, respectively) than in QFS patients who recovered from their complaints (medians 93.0 and 85.5 pg/mL, respectively) (p = 0.041 and 0.045, respectively). No significant differences between groups were found for C. burnetii-specific IL-2, CXCL9, and CXCL11 production. These findings point towards a difference in cell-mediated immunity in QFS patients with persisting complaints compared to those who recovered from their complaints. Such a difference may aid to eventually diagnose QFS more objectively and might serve as an indicator of its underlying etiology.
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Registered trials
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