Evidence map›Paper›PMID 29804263›Full record

ArticleCell and tissue research2018

Reabsorption in the proximal tubuli-ultrastructural evidence for a novel aspect of renal VEGF trafficking.

Marija Vitlov Uljević, Ivana Bočina, Ivana Restović, Nenad Kunac, Tomislav Mašek, Genia Kretzschmar, Maximilian Grobe, Mia Šarić, Katarina Vukojević, Mirna Saraga-Babić and 1 more

Abstract read
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In one paragraph

Article in Cell and tissue research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. A Homozygous Dab1Biomolecules · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Marija Vitlov UljevićDepartment of Anatomy, Histology and Embryology, Laboratory for Neurocardiology, University of Split School of Medicine, Šoltanska 2, 21000, Split, Croatia.
Ivana BočinaDepartment of Biology, University of Split Faculty of Science, Split, Croatia.
Ivana RestovićDepartment of Teacher Education, University of Split Faculty of Humanities and Social Sciences, Split, Croatia.
Nenad KunacDepartment of Pathology, University of Split School of Medicine, Split, Croatia.
Tomislav MašekDepartment of Animal Nutrition and Dietetics, University of Zagreb Faculty of Veterinary Medicine, Zagreb, Croatia.
Genia KretzschmarDepartment of Anatomy, Histology and Embryology, Laboratory for Neurocardiology, University of Split School of Medicine, Šoltanska 2, 21000, Split, Croatia.
Maximilian GrobeDepartment of Anatomy, Histology and Embryology, Laboratory for Neurocardiology, University of Split School of Medicine, Šoltanska 2, 21000, Split, Croatia.
Mia ŠarićDepartment of Anatomy, Histology and Embryology, Laboratory for Neurocardiology, University of Split School of Medicine, Šoltanska 2, 21000, Split, Croatia.
Katarina VukojevićDepartment of Anatomy, Histology and Embryology, Laboratory for Neurocardiology, University of Split School of Medicine, Šoltanska 2, 21000, Split, Croatia.
Mirna Saraga-BabićDepartment of Anatomy, Histology and Embryology, Laboratory for Early Human Development, University of Split School of Medicine, Split, Croatia.
Natalija FilipovićDepartment of Anatomy, Histology and Embryology, Laboratory for Neurocardiology, University of Split School of Medicine, Šoltanska 2, 21000, Split, Croatia. natalija.filipovic@mefst.hr.
University of Split · HRUniversity of Zagreb · HR

Funding

Hrvatska Zaklada za Znanost IP-2014-09-8992
6 · The paper itself

Abstract

Many clinical and experimental studies have revealed VEGF as an important factor in the pathophysiology of renal damage during diabetes mellitus (DM). Anti-VEGF therapy is in clinical use for treatment of DM and other diabetes-related (and unrelated) diseases. Nevertheless, little is known about the metabolism of VEGF in the kidneys. In order to determine the ultrastructural localization of VEGF in the kidney, we study the distribution of VEGF in the kidney of rats by using immunogold immunohistochemistry. Our light-microscopic data showed remarkable re-distribution of VEGF in proximal tubular cells (PTCs) during prolonged hyperglycemia, a DM type 2 model (DM2), which was confirmed by transmission electron microscopy (TEM) findings. TEM findings revealed an initial presence of VEGF in the vesicular transport apparatus of PTCs in healthy rats and its gradual translocation to the apical membrane of PTCs after renal damage caused by high sucrose treatment. The presented data add to our understanding of kidney VEGF trafficking, providing novel insight into the renal metabolism and pharmacodynamics of the cytokine. This could have a high impact on the use of VEGF and anti-VEGF therapy in different renal diseases.

Indexed as

AnimalsEndocytosisKidney Tubules, ProximalMaleRatsRats, WistarVascular Endothelial Growth Factor AVascular Endothelial Growth Factor ADiabetesEndocytosisHyperglycemiaRenal proximal tubuliVEGF

Identifiers

PMID29804263
OpenAlexW2803466345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.