ReviewMolecular neurobiology2019
The Role of the Periaqueductal Gray Matter in Lower Urinary Tract Function.
Review in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Review
- Phenotyping Overactive Bladder-Part 1: Are There Different Types of Urgency and Can They be Translated to Clinical, Urodynamic and Radiological Phenotyping? ICI-RS 2025.Neurourology and urodynamics · 2026Review
- Wireless electrostimulation implants enable sphincter neuromuscular improvement toward mixed urinary incontinence.Nature communications · 2026Article
- Plant-Derived Spinacetin Mitigates Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats.International journal of molecular sciences · 2026Article
- Altered Periaqueductal Gray Functional Connectivity in Overactive Bladder Patients: A Resting-State Functional Magnetic Resonance Imaging Study Using Clustering Analysis.International neurourology journal · 2025Article
- The mechanism of action of neuromodulation in the treatment of overactive bladder.Nature reviews. Urology · 2025Review
- SST neurons in the periaqueductal gray regulate urination and bladder function.Communications biology · 2025Article
- Periaqueductal gray subregions connectivity and its association with micturition desire-awakening function.European child & adolescent psychiatry · 2025Article
- Radiological features of gait phenotypes in patients with idiopathic normal pressure hydrocephalus.Frontiers in aging neuroscience · 2025Article
- Noradrenergic Pathways Involved in Micturition in an Animal Model of Hydrocephalus-Implications for Urinary Dysfunction.Biomedicines · 2024Article
- Lower urinary tract dysfunction following stroke: From molecular mechanisms to clinical anatomy.Journal of biological methods · 2024Review
- The contribution of periaqueductal gray in the regulation of physiological and pathological behaviors.Frontiers in neuroscience · 2024Review
- Decreased bladder contraction interval induced by periaqueductal grey stimulation is reversed by subthalamic stimulation in a Parkinson's disease model rat.IBRO neuroscience reports · 2023Article
- Lower Urinary Tract Disorders as Adverse Drug Reactions-A Literature Review.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Abnormal Resting-State Network Presence in Females with Overactive Bladder.Biomedicines · 2023Article
- Mechanism of traditional Chinese medicine in treating overactive bladder.International urology and nephrology · 2023Review
- Assessment of Brainstem Functional Organization in Healthy Adults and Overactive Bladder Patients Using Ultra-High Field fMRI.Biomedicines · 2023Article
- Urinary incontinence as a main clinical manifestation of early stage Wernicke's encephalopathy: a case report.Frontiers in neurology · 2023Article
- Early presentation of lower urinary tract and bowel dysfunction in sporadic amyotrophic lateral sclerosis: A case report.eNeurologicalSci · 2022Article
- Identification of the NADPH Oxidase (Nox) Subtype and the Source of Superoxide Production in the Micturition Centre.Biology · 2022Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The periaqueductal gray matter (PAG), as one of the mostly preserved evolutionary components of the brain, is an axial structure modulating various important functions of the organism, including autonomic, behavioral, pain, and micturition control. It has a critical role in urinary bladder physiology, with respect to storage and voiding of urine. The PAG has a columnar composition and has extensive connections with its cranially and caudally located components of the central nervous system (CNS). The PAG serves as the control tower of the detrusor and sphincter contractions. It serves as a bridge between the evolutionary higher decision-making brain centers and the lower centers responsible for reflexive micturition. Glutamatergic cells are the main operational neurons in the vlPAG, responsible for the reception and relay of the signals emerging from the bladder, to related brain centers. Functional imaging studies made it possible to clarify the activity of the PAG in voiding and filling phases of micturition, and its connections with various brain centers in living humans. The PAG may be affected in a wide spectrum of disorders, including multiple sclerosis (MS), migraine, stroke, Wernicke's encephalopathy, and idiopathic normal pressure hydrocephalus, all of which may have voiding dysfunction or incontinence, in certain stages of the disease. This emphasizes the importance of this structure for the basic understanding of voiding and storage disorders and makes it a potential candidate for diagnostic and therapeutic interventions.
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