Evidence map›Paper›PMID 29804135›Full record

ArticleApplied microbiology and biotechnology2018

Decontaminating surfaces with atomized disinfectants generated by a novel thickness-mode lithium niobate device.

Monika Kumaraswamy, Sean Collignon, Carter Do, Janie Kim, Victor Nizet, James Friend

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied microbiology and biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. HChemical engineering journal (Lausanne, Switzerland : 1996) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Monika KumaraswamyDivision of Infectious Diseases, University of California San Diego, 9500 Gilman Drive, Mail Code 0711, La Jolla, CA, 92093-0711, USA. mkumaraswamy@ucsd.edu.
Sean CollignonDepartment of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Carter DoDepartment of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA.
Janie KimDepartment of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA.
Victor NizetDepartment of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA.
James FriendDepartment of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, CA, 92093, USA.

Funding

Systems Biology Approach to Redefine Susceptibility Testing and Treatment of MDR Pathogens in the Context of Host ImmunityU01AI124316 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PALSSON, BERNHARD O · 2016 to 2020
$10.2M
Safety and Dose Optimization of High-Dose Anakinra in Kawasaki DiseaseU54HD090259 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIGAM, SANJAY K · 2016 to 2018
$2.2M
Surprising Efficacy of Discounted Antibiotics vs. MDR Gram-Negative Pathogens Occurring Through Innate Immune SensitizationR01AI145310 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMARASWAMY, MONIKA, NIZET, VICTOR · 2020 to 2023
$1.9M
Safety and Dose Optimization of High-Dose Anakinra in Kawasaki DiseaseP50HD090259 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CAPPARELLI, EDMUND VINCENT, NIZET, VICTOR · 2019 to 2020
$1.4M
National Science Foundation (US) 1542148NIAID NIH HHS R01 AI145310NIAID NIH HHS U01 AI124316NICHD NIH HHS P50 HD090259NICHD NIH HHS U54 HD090259Office of Naval Research (US) 12368098
6 · The paper itself

Abstract

We evaluated the ability of a novel lithium niobate (LN) thickness-mode device to atomize disinfectants and reduce microbial burden on model surface materials. A small-scale plastic model housed the LN thickness-mode device and circular coupon surface materials including polycarbonate, polyethylene terephthalate, stainless steel, borosilicate glass, and natural rubber. Coupon surfaces were coated with methicillin-resistant Staphylococcus aureus (MRSA) or multidrug-resistant (MDR) strains of Gram-negative bacterial pathogens (Klebsiella pneumoniae, Escherichia coli, and Acinetobacter baumannii), atomized with disinfectant solutions of varying viscosity (including 10% bleach, 70% ethanol (EtOH), or 25% triethylene glycol (TEG)) using the LN thickness-mode device, and assessed for surviving bacteria. The LN thickness-mode device effectively atomized disinfectants ranging from low viscosity 10% bleach solution or 70% EtOH to highly viscous 25% TEG. Coupons harboring MDR bacteria and atomized with 10% bleach solution or 70% EtOH were effectively decontaminated with ~ 100% bacterial elimination. Atomized 25% TEG effectively eliminated 100% of K. pneumoniae (CRE) from contaminated coupon surfaces but not MRSA. The enclosed small-scale plastic model established proof-of-principle that the LN thickness-mode device could atomize disinfectants of varying viscosities and decontaminate coupon surface materials harboring MDR organisms. Future studies evaluating scaled devices for patient rooms are warranted to determine their utility in hospital environmental decontamination.

Indexed as

Environmental MicrobiologyDecontaminationDisinfectantsDisinfectionEquipment ContaminationGram-Negative BacteriaMethicillin-Resistant Staphylococcus aureusNiobiumOxidesSurface PropertiesDisinfectantslithium niobateNiobiumOxidesDisinfectionLithium niobate thickness-mode deviceMultidrug-resistant bacteria

Identifiers

PMID29804135
PMCPMC6082180

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.