Evidence map›Paper›PMID 29804062›Full record

SynthesisBMJ open2018

Relevance of

Lei Zhong, Qi Fu, Shu Zhou, Lu Chen, Qian Peng

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lei ZhongPersonalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu, China.ORCID 0000-0002-1901-9698
Qi FuState Key Laboratory of Biotherapy and Cancer Center, West China Medical School, West China Hospital, Sichuan University, Chengdu, China.
Shu ZhouSchool of Life Sciences and Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Sichuan University, Chengdu, China.
Lu ChenPersonalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu, China.
Qian PengCancer Center, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the association between methylenetetrahydrofolate reductase (

designMeta-analysis.

methodsWe searched PubMed, Embase and Web of Science databases from inception up to October 2017 for relevant studies. The statistical analysis was performed using STATA V.12.0 software. The pooled ORs and 95% CIs were used to assess the strength of the association under the allele, dominant and recessive models. We also conducted subgroup analysis stratified by cancer type, ethnicity and study design. Additionally, the sensitivity analysis was performed by sequential omission of individual studies, and the publication bias was detected using both Begg's test and Egger's test.

resultsA total of 2020 patients from 12 studies were included in this meta-analysis. The results showed that there was no significant association between

conclusionsThis meta-analysis suggested that

Indexed as

AllelesAntimetabolites, AntineoplasticFemaleFluorouracilGastrointestinal NeoplasmsHumansMaleMethylenetetrahydrofolate Reductase (NADPH2)PharmacogeneticsPolymorphism, Single NucleotidePublication BiasRisk FactorsAntimetabolites, AntineoplasticFluorouracilMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanchemotherapy responsefluoropyrimidineMTHFROe sophagogastric cancerpolymorphism

Identifiers

PMID29804062
PMCPMC5988135

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.