Evidence map›Paper›PMID 29803593›Full record

ArticleAmerican journal of infection control2018

Evaluation of the antimicrobial efficacy and skin safety of a novel color additive in combination with chlorine disinfectants.

Kevin Tyan, Jason Kang, Katherine Jin, Aaron M Kyle

Abstract read
In one paragraph

Article in American journal of infection control, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Disinfectants In Interventional Practices.Current pain and headache reports · 2021
    Review
  5. Article
  6. Article
  7. International journal of microbiology · 2021
    Article
  8. Review
  9. COVID-19: Environment concern and impact of Indian medicinal system.Journal of environmental chemical engineering · 2020
    Review
  10. Hand disinfection in the combat against COVID-19.Journal of the European Academy of Dermatology and Venereology : JEADV · 2020
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kevin TyanKinnos Inc., 760 Parkside Avenue, Suite 215, Brooklyn, NY 11226. Electronic address: kevin@kinnos.us.
Jason KangKinnos Inc., 760 Parkside Avenue, Suite 215, Brooklyn, NY 11226.
Katherine JinKinnos Inc., 760 Parkside Avenue, Suite 215, Brooklyn, NY 11226.
Aaron M KyleDepartment of Biomedical Engineering, Columbia University, New York, New York.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveA novel color additive colorizes chlorine disinfectants blue to improve visibility and enhance spray surface coverage, and it fades to colorless to indicate elapsed contact time. We investigated its interactions with 3 chlorine disinfectants to determine if the additive would adversely affect the disinfectants' antimicrobial efficacy or skin safety.

methodsWe tested 0.5% sodium hypochlorite, 0.2% calcium hypochlorite, and 0.5% sodium dichloroisocyanurate (NaDCC) alone versus with color additive. An independent laboratory tested efficacy against Staphylococcus aureus, Pseudomonas aeruginosa, Vibrio cholerae, and human coronavirus 229E. An independent laboratory also tested direct skin irritation.

resultsChlorine disinfectants with and without color additive achieved equal levels of efficacy against the tested pathogens. Against S. aureus, 0.5% sodium hypochlorite with and without color additive met Environmental Protection Agency criteria for disinfection success. Against human coronavirus 229E, 0.5% sodium hypochlorite alone failed disinfection success criteria, whereas 0.5% sodium hypochlorite with color additive achieved full viral inactivation (≥4.50 log

conclusionsThis color additive can be combined with chlorine disinfectants without adversely affecting antimicrobial efficacy or skin safety.

Indexed as

BacteriaCalcium CompoundsColoring AgentsCoronavirusDisinfectantsHumansSkinSodium HypochloriteCalcium Compoundscalcium hypochloriteColoring AgentsDisinfectantsSodium HypochloriteAntimicrobial efficacyChlorine disinfectantColor additiveEfficacy testSkin irritationSkin safety

Identifiers

PMID29803593
PMCPMC7115331

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.