Evidence map›Paper›PMID 29803529›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2018

Resilience and White Matter Integrity in Geriatric Depression.

Roza M Vlasova, Prabha Siddarth, Beatrix Krause, Amber M Leaver, Kelsey T Laird, Natalie St Cyr, Katherine L Narr, Helen Lavretsky

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Resilience in Older People: A Concept Analysis.Healthcare (Basel, Switzerland) · 2023
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Promising Neuroimaging Biomarkers in Depression.Psychiatry investigation · 2019
    Article
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Roza M VlasovaSemel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA.
Prabha SiddarthSemel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA.
Beatrix KrauseSemel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA.
Amber M LeaverAhmanson-Lovelace Brain Mapping Center, Department of Neurology, University of California at Los Angeles, Los Angeles, CA.
Kelsey T LairdSemel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA.
Natalie St CyrSemel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA.
Katherine L NarrAhmanson-Lovelace Brain Mapping Center, Department of Neurology, University of California at Los Angeles, Los Angeles, CA.
Helen LavretskySemel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA. Electronic address: hlavretsky@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Brain connectivity and response to Tai Chi in geriatric depressionR01AT008383 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN · 2015 to 2019
$4.1M
Brain aging and treatment response in geriatric depressionR01MH097892 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN · 2013 to 2017
$3.5M
Methylphenidate Use to Improve Outcomes in Geriatric DepressionR01MH077650 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN · 2008 to 2012
$1.8M
Mentoring and Research in Translational Science of Integrative MedicineK24AT009198 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Helen Lavretsky · 2016 to 2026
$1.4M
Neurobiological Mechanisms of Treatment Response in Geriatric DepressionK24MH086481 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN · 2010 to 2014
$906k
Biomarkers of fast acting therapies in major depressionK24MH102743 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NARR, KATHERINE L · 2014 to 2018
$889k
NCCIH NIH HHS K24 AT009198NCCIH NIH HHS R01 AT008383NIMH NIH HHS K24 MH086481NIMH NIH HHS K24 MH102743NIMH NIH HHS R01 MH077650NIMH NIH HHS R01 MH097892
6 · The paper itself

Abstract

objectiveGreater psychological resilience may protect against developing depression in a growing geriatric population. Identifying the neural correlates of resilience in geriatric depression could provide neurobiologic targets to inform clinical interventions. However, most prior neuroimaging studies have only considered the presence or absence of resilience and have not addressed the multifactorial nature of resilience. The current study aimed to establish the neural correlates of four factors of resilience in the depressed elderly.

methodsWhite matter integrity was assessed using diffusion-weighted magnetic resonance imaging data collected from 70 older adults with major depressive disorder. We used four resilience factors previously derived in an exploratory factor analysis of the Connor-Davidson Resilience Scale in a large sample of depressed older adults: 1, grit; 2, active coping self-efficacy; 3, accommodative coping self-efficacy; and 4, spirituality.

resultsThe resilience factor "grit" was positively associated with fractional anisotropy in the callosal region connecting prefrontal cortex and fractional anisotropy in cingulum fibers; however, the latter did not survive correction for multiple comparisons.

conclusionStructural integrity of major white matter pathways implicated in cognitive control and emotion regulation (i.e., connecting prefrontal cortex) was positively associated with the resilience factor "grit" in our sample of older adults with depression. Prospective studies are needed to determine the utility of the structural integrity of these pathways as a biomarker in predicting risk for depression and treatment response.

Indexed as

Resilience, PsychologicalAgedAged, 80 and overAnisotropyDiffusion Magnetic Resonance ImagingFemaleHumansMajor Depressive DisorderMaleMiddle AgedNeuroimagingPrefrontal CortexWhite MatterConnor-Davidson Resilience ScaleDTIgeriatric depressiongritmajor depressive disorderMRIWhite matter

Identifiers

PMID29803529
PMCPMC6086733
OpenAlexW2801279598

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.