ArticleHeart & lung : the journal of critical care
Exploring the relationship between β-adrenergic receptor kinase-1 and physical symptoms in heart failure.
Article in Heart & lung : the journal of critical care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The trial behind it
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Hitting the (bio)mark Part 2: analysing, interpreting, and reporting biomarker data in cardiovascular research.European journal of cardiovascular nursing · 2024Review
- Sympathetic dysfunction is associated with worse fatigue and early and subtle symptoms in heart failure: an exploratory sex-stratified analysis.European journal of cardiovascular nursing · 2024Article
- Spanish version of the Heart Failure Somatic Perception Scale (HFSPS v.3) - psychometric properties.Frontiers in cardiovascular medicine · 2023Article
- Comparative symptom biochemistry between moderate and advanced heart failure.Heart & lung : the journal of critical care · 2018Article
- Cross-classification of physical and affective symptom clusters and 180-day event-free survival in moderate to advanced heart failure.Heart & lung : the journal of critical careArticle
- Heart Failure Symptom Biology in Response to Ventricular Assist Device Implantation.The Journal of cardiovascular nursingArticle
- Sympathetic Markers are Different Between Clinical Responders and Nonresponders After Left Ventricular Assist Device Implantation.The Journal of cardiovascular nursingArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe relationship between physical heart failure (HF) symptoms and pathophysiological mechanisms is unclear.
objectiveTo quantify the relationship between plasma β-adrenergic receptor kinase-1 (βARK1) and physical symptoms among adults with HF.
methodsWe performed a secondary analysis of data collected from two studies of adults with HF. Plasma βARK1 was quantified using an enzyme-linked immunosorbent assay. Physical symptoms were measured with the HF Somatic Perception Scale (HFSPS). Generalized linear modeling was used to quantify the relationship between βARK1 and HFSPS scores.
resultsThe average age (n = 94) was 54.5 ± 13.1 years, 76.6% were male, and a majority (83.0%) had Class III or IV HF. βARK1 was significantly associated with HFSPS scores (β = 0.22 ± 0.10, p = 0.038), adjusting for other predictors of physical symptoms (model R
conclusionsHigher βARK1 is associated with worse physical HF symptoms, pinpointing a potential pathophysiologic underpinning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.