ArticleNeuropsychologia2018
Mid-frontal theta activity is diminished during cognitive control in Parkinson's disease.
Article in Neuropsychologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06984757 (Mid-frontal Delta/Theta and Cognitive Control), which is not on this map. Cited by 56 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mid-frontal Delta/Theta and Cognitive Control
Who cites it
56 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Effectiveness and safety of theta burst stimulation for Parkinson's disease: an updated systematic review and meta-analysis of randomized parallel-group controlled trials.Frontiers in neurology · 2026Pooled it
- Efficacy of rTMS combined with cognitive training in TBI with cognition disorder: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Efficacy of intermittent theta burst stimulation (iTBS) on post-stroke cognitive impairment (PSCI): a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Comparative efficacy of transcranial magnetic stimulation on different targets in Parkinson's disease: A Bayesian network meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Characterization of EEG Data Revealing Relationships With Cognitive and Motor Symptoms in Parkinson's Disease: A Systematic Review.Frontiers in aging neuroscience · 2020Pooled it
- Theta tACS Over the Medial Frontal Cortex Modulates Executive Function in Parkinson's Disease: A Randomized, Sham-Controlled Study.CNS neuroscience & therapeutics · 2026Trial
- Neural mechanisms of awareness of action.PNAS nexus · 2026Article
- The use of electroencephalography in neurodegenerative disease and its utility in dementia.NPJ dementia · 2026Review
- A meta-analysis of periodic and aperiodic electrophysiological features in Parkinson's disease.Brain communications · 2026Review
- Cortical connectivity is associated with cognition across time in Parkinson's disease.Neuroimage. Reports · 2025Article
- Electrophysiological Signatures of Planned and Unplanned Continuous Movement Termination in Parkinson's Disease.eNeuro · 2025Article
- Dopaminergic modulation of behavioral and electrocortical markers of interpersonal performance monitoring in Parkinson's Disease.Communications biology · 2025Article
- Attentional dysfunction arises from right frontocentral and occipital network connectivity in Parkinson's disease.Neuroimage. Reports · 2025Article
- Cerebellar Oscillatory Patterns in Essential Tremor: Modulatory Effects of VIM-DBS.Cerebellum (London, England) · 2025Article
- Cognition falters at ~4 Hz in Parkinson's disease.Trends in cognitive sciences · 2024Article
- Multi-Scale Feature and Multi-Channel Selection toward Parkinson's Disease Diagnosis with EEG.Sensors (Basel, Switzerland) · 2024Article
- Prefrontal-subthalamic theta signaling mediates delayed responses during conflict processing.Progress in neurobiology · 2024Article
- Electrophysiological alterations during action semantic processing in Parkinson's disease.Neurobiology of aging · 2024Article
- Medication-invariant resting aperiodic and periodic neural activity in Parkinson's disease.Psychophysiology · 2024Article
- Effects of Game-Related Tasks for the Diagnosis and Classification of Gaming Disorder.Biosensors · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Mid-frontal theta activity underlies cognitive control. These 4-8 Hz rhythms are modulated by cortical dopamine and can be abnormal in patients with Parkinson's disease (PD). Here, we investigated mid-frontal theta deficits in PD patients during a task explicitly involving cognitive control. We collected scalp EEG from high-performing PD patients and demographically matched controls during performance of a modified Simon reaction-time task. This task involves cognitive control to adjudicate response conflict and error-related adjustments. Task performance of PD patients was indistinguishable from controls, but PD patients had less mid-frontal theta modulations around cues and responses. Critically, PD patients had attenuated mid-frontal theta activity specifically associated with response conflict and post-error processing. These signals were unaffected by medication or motor scores. Post-error mid-frontal theta activity was correlated with disease duration. Classification of control vs. PD from these data resulted in a specificity of 69% and a sensitivity of 72%. These findings help define the scope of mid-frontal theta aberrations during cognitive control in PD, and may provide insight into the nature of PD-related cognitive dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.