Evidence map›Paper›PMID 29802597›Full record

ArticleMolecular and cellular biochemistry2018

Developmental origins of pregnancy-induced cardiac changes: establishment of a novel model using the atrial natriuretic peptide gene-disrupted mice.

Nicole M Ventura, Terry Y Li, M Yat Tse, Logan Richard, Chandrakant Tayade, Albert Y Jin, R David Andrew, Stephen C Pang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nicole M VenturaDepartment of Biomedical and Molecular Sciences, Queen's University, Botterell Hall - 18 Stuart St., Kingston, ON, K7L 3N6, Canada.
Terry Y LiDepartment of Biomedical and Molecular Sciences, Queen's University, Botterell Hall - 18 Stuart St., Kingston, ON, K7L 3N6, Canada.
M Yat TseDepartment of Biomedical and Molecular Sciences, Queen's University, Botterell Hall - 18 Stuart St., Kingston, ON, K7L 3N6, Canada.
Logan RichardDepartment of Biomedical and Molecular Sciences, Queen's University, Botterell Hall - 18 Stuart St., Kingston, ON, K7L 3N6, Canada.
Chandrakant TayadeDepartment of Biomedical and Molecular Sciences, Queen's University, Botterell Hall - 18 Stuart St., Kingston, ON, K7L 3N6, Canada.
Albert Y JinDepartment of Biomedical and Molecular Sciences, Queen's University, Botterell Hall - 18 Stuart St., Kingston, ON, K7L 3N6, Canada.
R David AndrewDepartment of Biomedical and Molecular Sciences, Queen's University, Botterell Hall - 18 Stuart St., Kingston, ON, K7L 3N6, Canada.
Stephen C PangDepartment of Biomedical and Molecular Sciences, Queen's University, Botterell Hall - 18 Stuart St., Kingston, ON, K7L 3N6, Canada. pangsc@queensu.ca.
Queen's University · CAKingston General Hospital · CA

Funding

Heart and Stroke Foundation of Canada G-14-0006260Heart and Stroke Foundation of Canada T-6140
6 · The paper itself

Abstract

Pregnancy evokes many challenges on the maternal cardiovascular system that may unmask predispositions for future disease. This is particularly evident for women who develop pregnancy-related disorders, for example, pre-eclampsia and gestational diabetes or hypertension. Such pregnancy-related syndromes increase the risk for cardiovascular disease (CVD) postpartum. As a result, pregnancy has been termed as a cardiovascular stress test and an indicator or marker to predict the development of CVD later in life. In addition, pregnancy-related disorders impact the development of offspring also placing them at a higher risk for disease. Utilizing pregnancy as a physiological stressor, the current investigation sought to determine whether the cardiovascular system of offspring exposed to gestational hypertension in utero would respond adversely to the stress of pregnancy. Heterozygous atrial natriuretic peptide gene-disrupted (ANP

Indexed as

CardiomegalyPregnancy Complications, CardiovascularAnimalsAtrial Natriuretic FactorDisease Models, AnimalFemaleMaleMiceMice, KnockoutPregnancyAtrial Natriuretic FactorCardiac hypertrophyDevelopmental origins of diseaseGestational hypertensionNatriuretic peptide systemRenin-angiotensin system

Identifiers

PMID29802597
OpenAlexW2803829352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.