SynthesisLasers in medical science2018
Efficacy of low-level laser therapy in management of recurrent herpes labialis: a systematic review.
Synthesis in Lasers in medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Is low-level laser therapy effective in the treatment of herpes labialis? Systematic review and meta-analysis.Lasers in medical science · 2022Pooled it
- Efficacy of photobiomodulation therapy in recurrent herpes labialis management: a randomized controlled trial.Clinical oral investigations · 2024Trial
- Photobiomodulation therapy with an 830-nm light-emitting diode for the prevention of thyroidectomy scars: a randomized, double-blind, sham device-controlled clinical trial.Lasers in medical science · 2022Trial
- Photobiomodulation for Preventive Therapy of Recurrent Herpes Labialis: A 2-YearPhotobiomodulation, photomedicine, and laser surgery · 2022Trial
- Photobiomodulation in the management of oral lesions: a targeted, evidence-based approach.Brazilian oral research · 2026Review
- Photobiomodulation therapy.JADA foundational science · 2025Review
- Shedding light on Brazil's contribution to photobiomodulation research in oral medicine: a bibliometric study.Brazilian oral research · 2025Article
- Anxiety and Sun Exposure as Triggers for Herpes Labialis: A Case Report and Review of Literature.International medical case reports journal · 2025Article
- Investigating the safety of photobiomodulation in oral carcinogenesis: insights into cell proliferation, invasion, and apoptosis via the 4NQO model.Scientific reports · 2024Article
- A Comprehensive Overview of Epidemiology, Pathogenesis and the Management of Herpes Labialis.Viruses · 2023Review
- From the Cochrane Library: Interventions for the Prevention of Herpes Simplex Labialis (Cold Sores on the Lips).JMIR dermatology · 2022Article
- Low-Level Laser Therapy for Herpesvirus Infections: A Narrative Literature Review.Journal of lasers in medical sciences · 2021Review
- Evaluation of Efficacy of Low-Level Laser Therapy.Journal of lasers in medical sciences · 2020Review
- New Developments in Bacterial, Viral, and Fungal Cutaneous Infections.Current dermatology reports · 2020Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recurrent herpes labialis (RHL) is a highly prevalent viral infection that affects the oro-facial region. Current treatment options have limited efficacy in reducing healing time and recurrence rate of the disease. Recently, low-level laser therapy has been proposed as a potential treatment alternative for the management of RHL with no side effects. This systematic review aims to evaluate the effectiveness of laser therapy in the management and prevention of RHL. A comprehensive search of Medline/PubMed, Scopus, and Web of Science was carried out to identify published clinical trials comparing laser intervention to active and/or non-active controls for the treatment of RHL. Due to marked heterogeneity of available data, studies were assessed qualitatively, and no statistical analysis was performed. Of the retrieved 227 articles, six clinical trials met the eligibility criteria. The wavelengths, the power output, and energy density ranged between 632.5-870 nm, 5-80 W, and 2.04-48 J/cm
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.