Evidence map›Paper›PMID 29802545›Full record

ArticleWorld journal of pediatrics : WJP2018

Polymorphisms in the promoter region of IL10 gene are associated with virus etiology of infant bronchiolitis.

Annukka Holster, Johanna Teräsjärvi, Juho Vuononvirta, Petri Koponen, Ville Peltola, Merja Helminen, Qiushui He, Matti Korppi, Kirsi Nuolivirta

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Article in World journal of pediatrics : WJP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Annukka HolsterSeinäjoki Central Hospital, Hanneksenrinne 7, 60220, Seinäjoki, Finland.
Johanna TeräsjärviDepartment of Medical Microbiology and Immunology, Turku University, Turku, Finland.
Juho VuononvirtaDepartment of Medical Microbiology and Immunology, Turku University, Turku, Finland.
Petri KoponenTampere Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
Ville PeltolaDepartment of Pediatrics and Adolescent Medicine, Turku University Hospital and Child and Youth Research Institute, University of Turku, Turku, Finland.
Merja HelminenTampere Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
Qiushui HeDepartment of Medical Microbiology and Immunology, Turku University, Turku, Finland.
Matti KorppiTampere Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
Kirsi NuolivirtaSeinäjoki Central Hospital, Hanneksenrinne 7, 60220, Seinäjoki, Finland. kirsi.nuolivirta@fimnet.fi.ORCID http://orcid.org/0000-0002-2612-9449
University of Turku · FITampere University Hospital · FISeinäjoki University of Applied Sciences · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBronchiolitis is the most common infection leading to hospitalization in infancy. Interleukin-10 (IL-10) is an anti-inflammatory cytokine, and in our previous study, IL10 gene rs1800896 (- 1082A/G) polymorphism was associated with viral etiology of infant bronchiolitis. The objective of this study was to evaluate the associations between IL10 single nucleotide polymorphisms (SNPs) at rs1800890 (- 3575A/T), rs1800871 (- 819C/T) or rs1800872 (- 592C/A) either alone or combined with the SNP at rs1800896 (- 1082G/A), and the etiology and severity of infant bronchiolitis.

methodsData on four IL10 SNPs were available from 135 full-term infants, hospitalized for bronchiolitis at age less than 6 months, and from 378 to 400 controls. Viral etiology was studied, and oxygen support, feeding support and the length of stay in hospital were recorded during bronchiolitis hospitalization.

resultsInfants with rhinovirus bronchiolitis had the IL10 rs1800890 variant AT or TT genotype less often (18.2%) than controls (63.3%, P = 0.03), and likewise, had the IL10 rs1800896 variant AG or GG genotype less often (27.3%) than controls (65.5%, P = 0.009). Twenty-eight infants with bronchiolitis had the variant-variant G

conclusionIL10 rs1800890 and rs1800896 polymorphisms differed between infants with rhinovirus bronchiolitis and controls, but not between infants with respiratory syncytial virus bronchiolitis and controls.

Indexed as

Polymorphism, Single NucleotidePromoter Regions, GeneticBronchiolitisCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHaplotypesHumansInfantInfant, NewbornInterleukin-10MalePicornaviridae InfectionsRespiratory Syncytial Virus InfectionsRhinovirusIL10 protein, humanInterleukin-10BronchiolitisIL10 gene polymorphismInfantRespiratory syncytial virus

Identifiers

PMID29802545
OpenAlexW2804032118

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.