Evidence map›Paper›PMID 29802537›Full record

ArticleCell stress & chaperones2018

Drug-induced keratin 9 interaction with Hsp70 in bladder cancer cells.

C Andolino, C Hess, T Prince, H Williams, M Chernin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stress & chaperones, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Identification ofFrontiers in cell and developmental biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

C AndolinoBiology Department, Bucknell University, 1 Dent Drive, Lewisburg, PA, 17837, USA.
C HessBiology Department, Bucknell University, 1 Dent Drive, Lewisburg, PA, 17837, USA.
T PrinceDepartment of Urology, Geisinger Clinic, Danville, PA, USA.
H WilliamsDepartment of Urology, Geisinger Clinic, Danville, PA, USA.
M CherninBiology Department, Bucknell University, 1 Dent Drive, Lewisburg, PA, 17837, USA. chernin@bucknell.edu.ORCID http://orcid.org/0000-0002-5735-1309
Bucknell University · USGeisinger Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A pull-down experiment (co-immunoprecipitation) was performed on a T24 human bladder cancer cell lysate treated with the Hsp inhibitor VER155008 using an Hsp70 antibody attached to Dynabeads. Keratin 9, a cytoskeleton intermediate filament protein, was identified by LC MS/MS analysis. This novel finding was confirmed by Western blotting, RT-PCR, and immunocytochemistry. Other members of the keratin family of proteins have been shown to be involved in cancer progression, most recently identified to be associated with cell invasion and metastasis. The specific role of keratin 9 expression in these cells is yet to be determined.

Indexed as

Cell Line, TumorChromatography, LiquidHSP70 Heat-Shock ProteinsHumansImmunoprecipitationKeratin-9Purine NucleosidesTandem Mass SpectrometryUrinary Bladder NeoplasmsHSP70 Heat-Shock ProteinsKeratin-9KRT9 protein, humanPurine NucleosidesVER 155008Bladder cancerHsp70Keratin 9VER155008

Identifiers

PMID29802537
PMCPMC6111075
OpenAlexW2803350727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.