ArticleJournal of assisted reproduction and genetics2018
A new, simple, automatic vitrification device: preliminary results with murine and bovine oocytes and embryos.
Article in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 64 citations in OpenAlex.
- Seven Years of Vitrified Blastocyst Transfers: Comparison of 3 Preparation Protocols at a Single ART Center.Frontiers in endocrinology · 2020Trial
- Recent Advances and Emerging Applications in Embryo Vitrification for Livestock.Reproduction in domestic animals = Zuchthygiene · 2026Review
- Automation, Artificial Intelligence (AI), and Digital Management in IVF Laboratories: Current Status, Challenges and Potential.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Robotic cell transportation system based on micropipette resistance modeling.Microsystems & nanoengineering · 2026Article
- Integration of Bioengineered Tools in Assisted Reproductive Technologies.Advanced healthcare materials · 2025Review
- Automated device for rapid sample cooling via controlled submersion.Cryobiology · 2025Article
- Comparative Assessment of Morphometry, Morphology, and Maturation Capacity of Vitrified Cattle Oocytes in Different Media.Veterinary sciences · 2025Article
- Oocytes Vitrification Using Automated Equipment Based on Microfluidic Chip.Annals of biomedical engineering · 2025Article
- The protective effect of zinc oxide and selenium oxide nanoparticles on the functional parameters of rat sperm during vitrification.Clinical and experimental reproductive medicine · 2024Article
- Vitrification of human blastocysts for couples undergoing assisted reproduction: an updated review.Frontiers in cell and developmental biology · 2024Review
- Human sperm parameter improvement associated with Ceratonia siliqua extract as a cryopreservation supplement after vitrification.Clinical and experimental reproductive medicine · 2023Article
- Technologies for Vitrification Based Cryopreservation.Bioengineering (Basel, Switzerland) · 2023Review
- Automation in ART: Paving the Way for the Future of Infertility Treatment.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Genome transfer technique for bovine embryo production using the metaphase plate and polar body.Journal of assisted reproduction and genetics · 2023Article
- Automation in vitrification and thawing of mouse oocytes and embryos.Frontiers in cell and developmental biology · 2023Article
- Vitrification within a nanoliter volume: oocyte and embryo cryopreservation within a 3D photopolymerized device.Journal of assisted reproduction and genetics · 2022Article
- The Future of IVF: The New Normal in Human Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- The antioxidant roles of L-carnitine and N-acetyl cysteine against oxidative stress on human sperm functional parameters during vitrification.Clinical and experimental reproductive medicine · 2021Article
- ISAR Consensus Guidelines on Add-Ons Treatment inJournal of human reproductive sciences · 2021Article
- Strategies for cryopreservation of testicular cells and tissues in cancer and genetic diseases.Cell and tissue research · 2021Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
purposeThis paper reports the use of a novel automatic vitrification device (Sarah, Fertilesafe, Israel) for cryopreservation of oocytes and embryos.
methodsMice oocytes (n = 40) and embryos (8 cells, n = 35 and blastocysts, n = 165), bovine embryos (2PN, n = 35), and MII oocytes (n = 84) were vitrified using this automated device. A total of 42 (2 cells) mice embryos, 20 (2PN) bovine embryos, and 150 MII bovine oocytes were used as fresh controls and grown to blastocysts. Upon rewarming, all were assessed for viability, cleavage, blastocyst, and hatching rates.
resultsNinety-five % (38/40) of the mice MII oocytes regained isotonic volumes and all (100%) the surviving were viable. Rewarmed 8-cell mice embryos had 95% (33/35) blastulation rate and 80% (28/35) hatched. Rewarmed mice blastocysts had 97% survival rate (160/165) and 81% (135/165) hatched. Fresh control mice embryos had 100% (42/42) blastulation and 73% (21/42) hatching rates. Bovine embryos' survival was 100% with 54% (19/35) cleavage and 9% (3/35) blastulation rate. Fresh control bovine embryos had 65% (13/20) cleavage and 20% (4/20) blastulation rate. Vitrified bovine oocytes had 100% survival (84/84), 73% (61/84) cleavage, and 7% (6/84) blastocysts' rates; fresh control had 83% (125/150) cleavage and 11% (17/150) blastocysts' rates.
conclusionThis novel automatic vitrification device is capable to produce high survival rates of oocytes and embryos. We anticipate that as the demand for vitrification of gametes, embryos, and reproductive tissues increases worldwide, the availability of an automated vitrification device will become indispensable for standardization, simplification, and reproducibility of the entire process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.