Evidence map›Paper›PMID 29802406›Full record

ArticleNature cell biology2018

Spectrin is a mechanoresponsive protein shaping fusogenic synapse architecture during myoblast fusion.

Rui Duan, Ji Hoon Kim, Khurts Shilagardi, Eric S Schiffhauer, Donghoon M Lee, Sungmin Son, Shuo Li, Claire Thomas, Tianzhi Luo, Daniel A Fletcher and 2 more

Open access · greenAbstract readVideo-Audio Media
In one paragraph

Article in Nature cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Apical spectrin organizes cortical actin filament bundles to patternbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
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  14. The emergence of the stem cell niche.Trends in cell biology · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Generation of Cancer Stem/Initiating Cells by Cell-Cell Fusion.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Rui DuanDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ji Hoon KimDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Khurts ShilagardiDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Eric S SchiffhauerDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Donghoon M LeeDepartment of Molecular Biology, UT Southwestern Medical Center, Dallas, TX, USA.
Sungmin SonDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.
Shuo LiDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Claire ThomasDepartments of Biology and of Biochemistry and Molecular Biology, Penn State University, University Park, PA, USA.
Tianzhi LuoDepartment of Modern Mechanics, University of Science and Technology of China, Hefei, China.
Daniel A FletcherDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-1890-5364
Douglas N RobinsonDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Elizabeth H ChenDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Elizabeth.Chen@UTSouthwestern.edu.ORCID http://orcid.org/0000-0003-2707-6083
Johns Hopkins University · USUniversity of California, Berkeley · USPennsylvania State University · USSouthwestern Medical Center · USUniversity of Science and Technology of China · CN

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
The Biochemical Basis for the Mechanics of CytokinesisR01GM066817 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROBINSON, DOUGLAS N · 2003 to 2025
$7.3M
Molecular Mechanisms of Myoblast FusionR01AR053173 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, ELIZABETH H · 2006 to 2022
$5.3M
Dissecting the Mechanisms of Cell-Cell Fusion Using A Cell Culture SystemR01GM098816 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, ELIZABETH H · 2012 to 2019
$2.9M
Mechanical Regulation of Actin NetworksR01GM074751 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI FLETCHER, DANIEL A · 2008 to 2015
$2.4M
Force-Mediated Membrane FusionR01GM114671 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI FLETCHER, DANIEL A · 2016 to 2019
$1.4M
Force-sensitive macromolecular cytoskeletal assemblyR01GM109863 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROBINSON, DOUGLAS N, ROCK, RONALD S · 2014 to 2017
$1.1M
NIAMS NIH HHS R01 AR053173NIGMS NIH HHS R01 GM066817NIGMS NIH HHS R01 GM074751NIGMS NIH HHS R01 GM098816NIGMS NIH HHS R01 GM109863NIGMS NIH HHS R01 GM114671NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

Spectrin is a membrane skeletal protein best known for its structural role in maintaining cell shape and protecting cells from mechanical damage. Here, we report that α/β

Indexed as

Cell FusionMechanotransduction, CellularMembrane FusionAnimalsAnimals, Genetically ModifiedCell LineCell MembraneDrosophila melanogasterDrosophila ProteinsMiceMicroscopy, FluorescenceModels, BiologicalMyoblastsMyoblasts, SkeletalSpectrinStress, MechanicalDrosophila Proteinskst protein, DrosophilaSpectrin

Identifiers

PMID29802406
PMCPMC6397639
OpenAlexW2803507577

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.