ArticleScientific reports2018
OCT-Angiography reveals reduced vessel density in the deep retinal plexus of CADASIL patients.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Sex differences and risk factors for bleeding in Alagille syndrome.EMBO molecular medicine · 2022Pooled it
- Pooled it
- The Application of Optical Coherence Tomography Angiography in Cerebral Small Vessel Disease, Ischemic Stroke, and Dementia: A Systematic Review.Frontiers in neurology · 2020Pooled it
- Correlation analysis of physical fitness and retinal microvasculature by OCT angiography in healthy adults.PloS one · 2019Trial
- Deep Learning-Guided Retinal Vascular Morphometric Quantification in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Mouse Models.Ophthalmology science · 2026Article
- NOTCH3 Pathogenic Variant and Risk of Age-Related Macular Degeneration: Findings From the Taiwan Biobank and Small Vessel Disease Registry.Investigative ophthalmology & visual science · 2026Article
- An ensemble machine learning classifier for Parkinson's disease diagnosis using optical coherence tomography angiography.Scientific reports · 2026Article
- Macular vessel density is associated with cognitive function in preclinical p.R544C NOTCH3 mutation carriers.Journal of the Chinese Medical Association : JCMA · 2025Article
- OCTA changes of retinal microvessels and thickness in moyamoya disease.Scientific reports · 2025Article
- Decreased retinal vascular density is associated with cognitive impairment in CADASIL: an optical coherence tomography angiography study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Early remodeling and loss of light-induced dilation of retinal small arteries in CADASIL.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Reduced Retinal Blood Vessel Densities Measured by Optical Coherence Tomography Angiography in Keratoconus Patients Are Negatively Correlated with Keratoconus Severity.Diagnostics (Basel, Switzerland) · 2024Article
- Advances in retinal imaging biomarkers for the diagnosis of cerebrovascular disease.Frontiers in neurology · 2024Review
- Diffusion prepared pseudo-continuous arterial spin labeling reveals blood-brain barrier dysfunction in patients with CADASIL.European radiology · 2023Article
- Assessment of Microvascular Disease in Heart and Brain by MRI: Application in Heart Failure with Preserved Ejection Fraction and Cerebral Small Vessel Disease.Medicina (Kaunas, Lithuania) · 2023Review
- Retinal microvasculature is a potential biomarker for acute mountain sickness.Science China. Life sciences · 2023Article
- Disturbances of Ocular Circulation in Color Doppler Imaging, Retinal Changes and Electrophysiological Tests with Neuro-Ophthalmological Clinical Symptoms in the Course of CADASIL Syndrome-A Case Report.Journal of clinical medicine · 2023Article
- Assessment of Retinal Pigment Epithelium Alterations and Chorioretinal Vascular Network Analyses in Patients under Treatment with BRAF/MEK Inhibitor for Different Malignancies: A Pilot Study.Journal of clinical medicine · 2023Article
- Retinal vascular density in CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy).BMJ neurology open · 2023Article
- Detection of Stroke with Retinal Microvascular Density and Self-Supervised Learning Using OCT-A and Fundus Imaging.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optical coherence tomography angiography (OCT-A) represents the most recent tool in ophthalmic imaging. It allows for a non-invasive, depth-selective and quantitative visualization of blood flow in central retinal vessels and it has an enormous diagnostic potential not only in ophthalmology but also with regards to neurologic and systemic diseases. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary vascular small-vessel disease caused by Notch3 mutations and represents the most common form of hereditary stroke disorder. In this study, CADASIL patients prospectively underwent OCT-A imaging to evaluate retinal and choriocapillaris blood flow as well as blood flow at the optic nerve head. The vessel density of the macular region and the size of the foveal avascular zone in the superficial and deep retinal plexus were determined as well as the vessel density at the optic nerve head and in the choriocapillaris. Additionally, cerebral magnetic resonance images were evaluated. The main finding was that vessel density of the deep retinal plexus was significantly decreased in CADASIL patients compared to healthy controls which may reflect pericyte dysfunction in retinal capillaries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.