ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018
Differences in the subjective and motivational properties of alcohol across alcohol use severity: application of a novel translational human laboratory paradigm.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Naltrexone effects on subjective responses to alcohol in the human laboratory: A systematic review and meta-analysis.Addiction biology · 2019Pooled it
- Evaluation of glycine treatment for reducing alcohol craving and self-administration in individuals with alcohol use disorder: A human laboratory trial.Alcohol, clinical & experimental research · 2025Trial
- Across the spectrum: Acute alcohol responses in young adults with mild, moderate, and severe alcohol use disorder.Drug and alcohol dependence · 2025Trial
- Using naltrexone to validate a human laboratory test system to screen new medications for alcoholism (TESMA)- a randomized clinical trial.Translational psychiatry · 2023Trial
- A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consumption: lessons learned from a human laboratory investigation.Molecular psychiatry · 2021Trial
- The Interplay Between Subjective Response to Alcohol, Craving, and Alcohol Self-Administration in the Human Laboratory.Alcoholism, clinical and experimental research · 2019Trial
- Subjective response to alcohol predicts motivation to self-administer alcohol in a progressive ratio task.Experimental and clinical psychopharmacology · 2025Article
- Influence of real-world cue exposure and mood states on drinking: testing neurobiological models of alcohol use disorder.Psychopharmacology · 2025Article
- Are you feeling what I'm feeling? Momentary interactions between personal and perceived peer subjective response predict craving and continued drinking in young adults.Drug and alcohol dependence · 2025Article
- High-intensity sweet taste as a predictor of subjective alcohol responses to the ascending limb of an intravenous alcohol prime: an fMRI study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Free-access intravenous alcohol self-administration in social drinkers and individuals with alcohol use disorder: Evaluation of relationships with phosphatidylethanol and self-reported alcohol consumption.Alcohol, clinical & experimental research · 2023Article
- Translational models of addiction phenotypes to advance addiction pharmacotherapy.Annals of the New York Academy of Sciences · 2023Review
- Momentary subjective responses to alcohol as predictors of continuing to drink during daily-life drinking episodes.Drug and alcohol dependence · 2022Article
- Cannabis use and subjective response to alcohol in the human laboratory.Drug and alcohol dependence · 2022Article
- Additive roles of tobacco and cannabis co-use in relation to delay discounting in a sample of heavy drinkers.Psychopharmacology · 2022Article
- Sex moderates effects of alcohol and cannabis co-use on alcohol and stress reactivity.Alcoholism, clinical and experimental research · 2022Article
- Moderators of subjective response to alcohol in the human laboratory.Alcoholism, clinical and experimental research · 2022Article
- Sex-dependent effects of alcohol administration on the urge to use cannabis.Experimental and clinical psychopharmacology · 2021Article
- Translating preclinical models of alcohol seeking and consumption into the human laboratory using intravenous alcohol self-administration paradigms.Addiction biology · 2021Article
- Translational opportunities in animal and human models to study alcohol use disorder.Translational psychiatry · 2021Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The Allostatic Model proposes that Alcohol Use Disorder (AUD) is associated with a transition in the motivational structure of alcohol drinking: from positive reinforcement in early-stage drinking to negative reinforcement in late-stage dependence. However, direct empirical support for this preclinical model from human experiments is limited. This study tests predictions derived from the Allostatic Model in humans. Specifically, this study tested whether alcohol use severity (1) independently predicts subjective responses to alcohol (SR; comprised of stimulation/hedonia, negative affect, sedation and craving domains), and alcohol self-administration and 2) moderates associations between domains of SR and alcohol self-administration. Heavy drinking participants ranging in severity of alcohol use and problems (N = 67) completed an intravenous alcohol administration paradigm combining an alcohol challenge (target BrAC = 60 mg%), with progressive ratio self-administration. Alcohol use severity was associated with greater baseline negative affect, sedation, and craving but did not predict changes in any SR domain during the alcohol challenge. Alcohol use severity also predicted greater self-administration. Craving during the alcohol challenge strongly predicted self-administration and sedation predicted lower self-administration. Neither stimulation, nor negative affect predicted self-administration. This study represents a novel approach to translating preclinical neuroscientific theories to the human laboratory. As expected, craving predicted self-administration and sedation was protective. Contrary to the predictions of the Allostatic Model, however, these results were inconsistent with a transition from positively to negatively reinforced alcohol consumption in severe AUD. Future studies that assess negative reinforcement in the context of an acute stressor are warranted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.