ArticleScientific reports2018
Engineered Healing of Avascular Meniscus Tears by Stem Cell Recruitment.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meniscal repair: The current state and recent advances in augmentation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Pooled it
- Meniscus Repair and Regeneration: A Systematic Review from a Basic and Translational Science Perspective.Clinics in sports medicine · 2020Pooled it
- Multi-Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Multi-functional Small Molecule for Regenerative Healing of Avascular Meniscus Tears: Modulation of Inflammation, Differentiation, and Multi-Tissue Crosstalk.Theranostics · 2026Article
- Exploring bioadhesion: insight on innovative strategies to investigate bioadhesive scaffolds.International journal of pharmaceutics: X · 2025Review
- High-intensity running exercise promotes knee meniscal damage via the PI3K/AKT/mTOR axis.Bone & joint research · 2025Article
- Bioactive scaffolds integrated with micro-precise spatiotemporal delivery andEngineered regeneration · 2025Article
- Hydrogel Design to Understand and Guide 3D Cell Migration.Regenerative engineering and translational medicine · 2025Review
- Current advances in animal model of meniscal injury: From meniscal injury to osteoarthritis.Journal of orthopaedic translation · 2025Review
- Icariin-Releasing 3-Dimensionally Printed Scaffolds for Alveolar Cleft Reconstruction.Biomaterials research · 2025Article
- Cell-based therapy in the treatment of musculoskeletal diseases.Stem cells translational medicine · 2024Review
- Viable Vitreous Grafts of Whole Porcine Menisci for Transplant in the Knee and Temporomandibular Joints.Advanced healthcare materials · 2024Article
- Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives.Gels (Basel, Switzerland) · 2024Review
- Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial.Signal transduction and targeted therapy · 2023Article
- Advanced bioactive glue tethering Lubricin/PRG4 to promote integrated healing of avascular meniscus tears.Bioactive materials · 2023Article
- Biomolecule-releasing bioadhesive for glenoid labrum repair through induced host progenitor cell responses.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Adhesive hydrogels in osteoarthritis: from design to application.Military Medical Research · 2023Review
- Regeneration of meniscal avascular zone using autogenous meniscal fragments in a rabbit model.BMC surgery · 2022Article
- Meniscus repair: up-to-date advances in stem cell-based therapy.Stem cell research & therapy · 2022Review
- Synovial membrane mesenchymal stem cells for cartilaginous tissues repair.Molecular biology reports · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Meniscus injuries are extremely common with approximately one million patients undergoing surgical treatment annually in the U.S. alone. Upon injury, the outer zone of the meniscus can be repaired and expected to functionally heal but tears in the inner avascular region are unlikely to heal. To date, no regenerative therapy has been proven successful for consistently promoting healing in inner-zone meniscus tears. Here, we show that controlled applications of connective tissue growth factor (CTGF) and transforming growth factor beta 3 (TGFβ3) can induce seamless healing of avascular meniscus tears by inducing recruitment and step-wise differentiation of synovial mesenchymal stem/progenitor cells (syMSCs). A short-term release of CTGF, a selected chemotactic and profibrogenic cue, successfully recruited syMSCs into the incision site and formed an integrated fibrous matrix. Sustain-released TGFβ3 then led to a remodeling of the intermediate fibrous matrix into fibrocartilaginous matrix, fully integrating incised meniscal tissues with improved functional properties. Our data may represent a novel clinically relevant strategy to improve healing of avascular meniscus tears by recruiting endogenous stem/progenitor cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.