ArticleScientific reports2018
Dissecting Clinical and Metabolomics Associations of Left Atrial Phasic Function by Cardiac Magnetic Resonance Feature Tracking.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05946174 (Tackling Disruptions to Frailty Interventions), which is not on this map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Tackling Disruptions to Frailty Interventions: Developing Personalized Interventions Targeted for Older Persons With Cardiac Frailty
Who cites it
24 citing papers in PubMed, 28 citations in OpenAlex.
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- Superior aortic strain and ventriculoarterial coupling in older women are moderately correlated with Framingham 10-year risk.European heart journal. Imaging methods and practice · 2025Article
- Longitudinal aortic strain, ventriculo-arterial coupling and fatty acid oxidation: novel insights into human cardiovascular aging.GeroScience · 2024Observational
- Cardiovascular Aging and Risk Assessment: How Multimodality Imaging Can Help.Diagnostics (Basel, Switzerland) · 2024Review
- Heart-brain mapping: Cardiac atrial function is associated with distinct cerebral regions with high free water in older adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Characteristics of pulmonary artery strain assessed by cardiovascular magnetic resonance imaging and associations with metabolomic pathways in human ageing.Frontiers in cardiovascular medicine · 2024Article
- Phenomic Imaging.Phenomics (Cham, Switzerland) · 2023Review
- Adverse cardiovascular and metabolic perturbations among older women: 'fat-craving' hearts.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Effect of psychosocial motivations and technology on physical activity behaviours among community older men and women.BMC geriatrics · 2022Article
- Obesity in Older Adults and Associations with Cardiovascular Structure and Function.Obesity facts · 2022Observational
- Exacerbation of cardiovascular ageing by diabetes mellitus and its associations with acyl-carnitines.Aging · 2021Article
- Metabolomics and cardiovascular imaging: a combined approach for cardiovascular ageing.ESC heart failure · 2021Review
- Article
- Age- and Sex-Specific Changes in CMR Feature Tracking-Based Right Atrial and Ventricular Functional Parameters in Healthy Asians.Frontiers in cardiovascular medicine · 2021Article
- Associations between cardiac function and retinal microvascular geometry among Chinese adults.Scientific reports · 2020Article
- Exploring Associations Between Cardiac Structure and Retinal Vascular Geometry.Journal of the American Heart Association · 2020Article
- Associations between Skeletal Muscle and Myocardium in Aging: A Syndrome of "Cardio-Sarcopenia"?Journal of the American Geriatrics Society · 2019Article
- Galectin-3 as a candidate upstream biomarker for quantifying risks of myocardial ageing.ESC heart failure · 2019Article
- Age-related changes in four-dimensional CMR-derived atrioventricular junction velocities and displacements: Implications for the identification of altered annular dynamics for ventricular function assessment.International journal of cardiology. Heart & vasculature · 2019Article
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Among community cohorts, associations between clinical and metabolite factors and complex left atrial (LA) phasic function assessed by cardiac magnetic resonance (CMR) feature tracking (FT) are unknown. Longitudinal LA strain comprising reservoir strain (εs), conduit strain (εe) and booster strain (εa) and their corresponding peak strain rates (SRs, SRe, SRa) were measured using CMR FT. Targeted mass spectrometry measured 83 circulating metabolites in serum. Sparse Principal Component Analysis was used for data reduction. Among community adults (n = 128, 41% female) (mean age: 70.5 ± 11.6 years), age was significantly associated with εs (β = -0.30, p < 0.0001), εe (β = -0.3, p < 0.0001), SRs (β = -0.02, p < 0.0001), SRe (β = 0.04, p < 0.0001) and SRe/SRa (β = -0.01, p = 0.012). In contrast, heart rate was significantly associated with εa (β = 0.1, p = 0.001) and SRa (β = -0.02, p < 0.0001). Serine was significantly associated with εs (β = 10.1, p = 0.015), SRs (β = 0.5, p = 0.033) and SRa (β = -0.9, p = 0.016). Citrulline was associated with εs (β = -4.0, p = 0.016), εa (β = -3.4, p = 0.002) and SRa (β = 0.4, p = 0.019). Valine was associated with ratio of SRe:SRa (β = -0.4, p = 0.039). Medium and long chain dicarboxyl carnitines were associated with εs (β = -0.6, p = 0.038). Phases of LA function were differentially associated with clinical and metabolite factors. Metabolite signals may be used to advance mechanistic understanding of LA disease in future studies.
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