ArticleScientific reports2018
Penetrating cations induce pleiotropic drug resistance in yeast.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Mode of the Interaction of Efflux Inhibitor Phenylalanyl-arginyl-β-naphtylamide with Bacterial Cells.Biomedicines · 2024Article
- Toxic Effects of Penetrating Cations.Membranes · 2023Review
- Tyrosol induces multiple drug resistance in yeastFrontiers in microbiology · 2023Article
- MDR Pumps as Crossroads of Resistance: Antibiotics and Bacteriophages.Antibiotics (Basel, Switzerland) · 2022Review
- Theoretical and Experimental Studies of Phosphonium Ionic Liquids as Potential Antibacterials of MDRAntibiotics (Basel, Switzerland) · 2022Article
- Protonophore FCCP provides fitness advantage to PDR-deficient yeast cells.Journal of bioenergetics and biomembranes · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Substrates of pleiotropic drug resistance (PDR) transporters can induce the expression of corresponding transporter genes by binding to their transcription factors. Penetrating cations are substrates of PDR transporters and theoretically may also activate the expression of transporter genes. However, the accumulation of penetrating cations inside mitochondria may prevent the sensing of these molecules. Thus, whether penetrating cations induce PDR is unclear. Using Saccharomyces cerevisiae as a model, we studied the effects of penetrating cations on the activation of PDR. We found that the lipophilic cation dodecyltriphenylphosphonium (C
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