ArticleEmerging microbes & infections2018
A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and Heartland virus, is a potential pathogen.
Article in Emerging microbes & infections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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83 citing papers in PubMed, 134 citations in OpenAlex.
- Article
- Human 3D liver spheroids support productive infection of a novel tick-borne phenuivirus.One health (Amsterdam, Netherlands) · 2026Article
- Ecological factors and genetic features are associated with ecological generalism in pathogenic tick-borne viruses.Nature communications · 2026Article
- New Data on Ixodid Ticks and Their Infection withTropical medicine and infectious disease · 2026Article
- Extending the temporal window of arbovirus evolutionary analysis through the recovery of a century-old bandavirus.Virus evolution · 2026Article
- Research progress on antiviral drugs and vaccines for severe fever with thrombocytopenia syndrome.Frontiers in immunology · 2026Review
- Co-Circulation of Tick-BorneViruses · 2025Article
- First genetic characterization and phylogenetic analysis of Okutama tick virus in a tick collected from a raccoon dog (Nyctereutes procyonoides) in South Korea.Virology journal · 2025Article
- Article
- Contributions of different host species to the natural transmission of severe fever with thrombocytopenia syndrome virus in China.PLoS neglected tropical diseases · 2025Article
- The public health threat of emerging phenuiviruses.One health (Amsterdam, Netherlands) · 2025Review
- Article
- Thrombocytopenia in Severe Fever with Thrombocytopenia Syndrome Due to Platelets With Altered Function Undergoing Cell Death Pathways.The Journal of infectious diseases · 2025Article
- Metagenomic Analysis of Tick-Borne Viruses Associated WithTransboundary and emerging diseases · 2025Article
- Virome analysis and detection of ticks and tick-borne viruses in Shanghai, China.Frontiers in microbiology · 2025Article
- Decoding broadly neutralizing antibodies: a milestone in SFTSV therapy.EBioMedicine · 2025Article
- Article
- Article
- Tick-borne viruses: Epidemiology, pathogenesis, and animal models.One health (Amsterdam, Netherlands) · 2024Review
- Review
23 more citing papers are in PubMed but not listed here.
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Authors and funding
24 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tick-borne viral diseases have attracted much attention in recent years because of their increasing incidence and threat to human health. Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV) and Heartland virus (HRTV) were recently identified as tick-borne phleboviruses (TBPVs) in Asia and the United States, respectively, and are associated with severe human diseases with similar clinical manifestations. In this study, we report the first identification and isolation of a novel TBPV named Guertu virus (GTV) from Dermacentor nuttalli ticks in Xinjiang Province, China, where TBPVs had not been previously discovered. Genome sequence and phylogenetic analyses showed that GTV is closely related to SFTSV and HRTV and was classified as a member of the genus Phlebovirus, family Phenuiviridae, order Bunyavirales. In vitro and in vivo investigations of the properties of GTV demonstrated that it was able to infect animal and human cell lines and can suppress type I interferon signaling, similar to SFTSV, that GTV nucleoprotein (NP) can rescue SFTSV replication by replacing SFTSV NP, and that GTV infection can cause pathological lesions in mice. Moreover, a serological survey identified antibodies against GTV from serum samples of individuals living in Guertu County, three of which contained neutralizing antibodies, suggesting that GTV can infect humans. Our findings suggested that this virus is a potential pathogen that poses a threat to animals and humans. Further studies and surveillance of GTV are recommended to be carried out in Xinjiang Province as well as in other locations.
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