ArticleNature communications2018
Photonic force optical coherence elastography for three-dimensional mechanical microscopy.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Multimodal mechano-microscopy reveals mechanical phenotypes of breast cancer spheroids in three dimensions.APL bioengineering · 2024Article
- Recent advances in optical elastography and emerging opportunities in the basic sciences and translational medicine [Invited].Biomedical optics express · 2023Review
- Light-sheet photonic force optical coherence elastography for high-throughput quantitative 3D micromechanical imaging.Nature communications · 2022Article
- Introduction to optical coherence elastography: tutorial.Journal of the Optical Society of America. A, Optics, image science, and vision · 2022Article
- Single-cell all-optical coherence elastography with optical tweezers.Biomedical optics express · 2022Article
- Article
- Computational 4D-OCM for label-free imaging of collective cell invasion and force-mediated deformations in collagen.Scientific reports · 2021Article
- Valve endothelial-interstitial interactions drive emergent complex calcific lesion formation in vitro.Biomaterials · 2021Article
- Quantitative measurement of mechanical properties in wound healing processes in a corneal stroma model by using vibrational optical coherence elastography (OCE).Biomedical optics express · 2021Article
- Stiffness Sensing by Cells.Physiological reviews · 2020Review
- Ultrahigh-sensitive optical coherence elastography.Light, science & applications · 2020Article
- Advances in Doppler optical coherence tomography and angiography.Translational biophotonics · 2019Article
- Spatial localization of mechanical excitation affects spatial resolution, contrast, and contrast-to-noise ratio in acoustic radiation force optical coherence elastography.Biomedical optics express · 2019Article
- Spectroscopic photonic force optical coherence elastography.Optics letters · 2019Article
- Microrheological quantification of viscoelastic properties with photonic force optical coherence elastography.Optics express · 2019Article
- Quantitative reconstruction of time-varying 3D cell forces with traction force optical coherence microscopy.Scientific reports · 2019Article
- Optical pulling at macroscopic distances.Science advances · 2019Article
- Analysis of spatial resolution in phase-sensitive compression optical coherence elastography.Biomedical optics express · 2019Article
- Interstitial magnetic thermotherapy dosimetry based on shear wave magnetomotive optical coherence elastography.Biomedical optics express · 2019Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optical tweezers are an invaluable tool for non-contact trapping and micro-manipulation, but their ability to facilitate high-throughput volumetric microrheology of biological samples for mechanobiology research is limited by the precise alignment associated with the excitation and detection of individual bead oscillations. In contrast, radiation pressure from a low-numerical aperture optical beam can apply transversely localized force over an extended depth range. Here we present photonic force optical coherence elastography (PF-OCE), leveraging phase-sensitive interferometric detection to track sub-nanometer oscillations of beads, embedded in viscoelastic hydrogels, induced by modulated radiation pressure. Since the displacements caused by ultra-low radiation-pressure force are typically obscured by absorption-mediated thermal effects, mechanical responses of the beads were isolated after independent measurement and decoupling of the photothermal response of the hydrogels. Volumetric imaging of bead mechanical responses in hydrogels with different agarose concentrations by PF-OCE was consistent with bulk mechanical characterization of the hydrogels by shear rheometry.
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