Evidence map›Paper›PMID 29802230›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Heme redox potentials hold the key to reactivity differences between nitric oxide reductase and heme-copper oxidase.

Ambika Bhagi-Damodaran, Julian H Reed, Qianhong Zhu, Yelu Shi, Parisa Hosseinzadeh, Braddock A Sandoval, Kevin A Harnden, Shuyan Wang, Madeline R Sponholtz, Evan N Mirts and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Structure and Nitrite Reductase Activity of the Di-iron Protein ScdA inJournal of the American Chemical Society · 2025
    Article
  7. Article
  8. One-Electron NO to NChemistry (Weinheim an der Bergstrasse, Germany) · 2024
    Article
  9. Article
  10. Article
  11. Metalloprotein enabled redox signal transduction in microbes.Current opinion in chemical biology · 2023
    Review
  12. Article
  13. Article
  14. Tailorable Tetrahelical Bundles as a Toolkit for Redox Studies.The journal of physical chemistry. B · 2022
    Article
  15. Review
  16. Article
  17. A Nonheme Mononuclear {FeNO}Angewandte Chemie (International ed. in English) · 2021
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ambika Bhagi-DamodaranDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Julian H ReedDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Qianhong ZhuDivision of Environmental & Biomolecular Systems, Oregon Health & Science University, Portland, OR 97239.
Yelu ShiDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ 07030.
Parisa HosseinzadehDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Braddock A SandovalDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Kevin A HarndenDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Shuyan WangDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Madeline R SponholtzDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Evan N MirtsCenter for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Sudharsan DwaraknathDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Yong ZhangDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ 07030; yi-lu@illinois.edu yong.zhang@stevens.edu moennelo@ohsu.edu.
Pierre Moënne-LoccozDivision of Environmental & Biomolecular Systems, Oregon Health & Science University, Portland, OR 97239; yi-lu@illinois.edu yong.zhang@stevens.edu moennelo@ohsu.edu.ORCID 0000-0002-7684-7617
Yi LuDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801; yi-lu@illinois.edu yong.zhang@stevens.edu moennelo@ohsu.edu.ORCID 0000-0003-1221-6709

Funding

Nitric Oxide Reactions in MetalloenzymesR01GM074785 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI MOENNE-LOCCOZ, PIERRE · 2006 to 2019
$3.8M
NIGMS NIH HHS R01 GM074785
6 · The paper itself

Abstract

Despite high structural homology between NO reductases (NORs) and heme-copper oxidases (HCOs), factors governing their reaction specificity remain to be understood. Using a myoglobin-based model of NOR (Fe

Indexed as

HemeOxidoreductasesBacterial ProteinsHistidineKineticsModels, MolecularNitric OxideOxidation-ReductionSpectrum AnalysisBacterial Proteinscopper oxidaseHemeHistidineNitric Oxidenitric-oxide reductaseOxidoreductasesbiomimeticsheme-copper oxidasemetalloprotein designnitric oxide reductaseredox potentials

Identifiers

PMID29802230
PMCPMC6004492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.