Evidence map›Paper›PMID 29802203›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Copine-6 Binds to SNAREs and Selectively Suppresses Spontaneous Neurotransmission.

Pei Liu, Mikhail Khvotchev, Ying C Li, Natali L Chanaday, Ege T Kavalali

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Loss of Copine D Leads to Ras Activation inbioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Spatially non-overlapping CaCell reports · 2023
    Article
  8. Article
  9. Stochastic Properties of Spontaneous Synaptic Transmission at Individual Active Zones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. High expression of CPNE5 and CPNE9 predicts positive prognosis in multiple myeloma.Cancer biomarkers : section A of Disease markers · 2021
    Article
  14. VAMP4 Maintains a CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pei LiuDepartments of Neuroscience and.
Mikhail KhvotchevDepartments of Neuroscience and.
Ying C LiDepartments of Neuroscience and.ORCID 0000-0003-4216-6183
Natali L ChanadayDepartments of Neuroscience and.ORCID 0000-0002-3376-5187
Ege T KavalaliDepartments of Neuroscience and Ege.Kavalali@UTSouthwestern.edu.ORCID 0000-0003-1777-227X

Funding

Role of SNARE Interactions in Central Synapse FunctionR01MH066198 · NIMH · VANDERBILT UNIVERSITY · PI KAVALALI, EGE T · 2004 to 2023
$7.9M
NIMH NIH HHS R01 MH066198
6 · The paper itself

Abstract

Recent studies suggest that spontaneous and action potential-evoked neurotransmitter release processes are independently regulated. However, the mechanisms that uncouple the two forms of neurotransmission remain unclear. In cultured mouse and rat neurons, we show that the two C2 domain-containing protein copine-6 is localized to presynaptic terminals and binds to synaptobrevin2 as well as other SNARE proteins in a Ca

Indexed as

AnimalsCarrier ProteinsCells, CulturedHumansMiceNeuronsRatsRats, Sprague-DawleySNARE ProteinsSynaptic TransmissionCarrier ProteinscopineSNARE Proteinscalcium regulation of releasespontaneous neurotransmissionsynaptic vesicle fusion

Identifiers

PMID29802203
PMCPMC6021993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.