Evidence map›Paper›PMID 29802197›Full record

ArticleThe Journal of biological chemistry2018

Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K

Lan Cheng, Moza Al-Owais, Manuel L Covarrubias, Walter J Koch, David R Manning, Chris Peers, Natalia A Riobo-Del Galdo

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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  3. Article
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  7. GFrontiers in aging neuroscience · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Lan ChengFrom the Departments of Biochemistry & Molecular Biology and.
Moza Al-Owaisthe Leeds Institute of Cardiovascular and Metabolic Medicine and.
Manuel L CovarrubiasNeuroscience, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Walter J Kochthe Department of Pharmacology and Center for Translational Medicine, Temple University, Philadelphia, Pennsylvania 19140, and.
David R Manningthe Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104.
Chris Peersthe Leeds Institute of Cardiovascular and Metabolic Medicine and.
Natalia A Riobo-Del GaldoFrom the Departments of Biochemistry & Molecular Biology and n.a.riobo-delgaldo@leeds.ac.uk.ORCID 0000-0002-8942-7873
University of Leeds · GBThomas Jefferson University · USTemple University · USTranslational Therapeutics (United States) · US

Funding

Targeting GRK2 in the HeartR01HL061690 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI KOCH, WALTER J. · 1998 to 2022
$4.2M
Engagement of heterotrimeric G proteins by Sonic hedgehogR01GM080396 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MANNING, DAVID RANDELL, RIOBO-DEL GALDO, NATALIA ANDREA · 2007 to 2017
$3.1M
NHLBI NIH HHS R01 HL061690NIGMS NIH HHS R01 GM080396
6 · The paper itself

Abstract

SMO (Smoothened), the central transducer of Hedgehog signaling, is coupled to heterotrimeric G

Indexed as

Action PotentialsAnimalsCells, CulturedGTP-Binding Protein alpha Subunits, Gi-GoHedgehog ProteinsIon Channel GatingMiceMice, TransgenicMyocytes, CardiacPotassiumPotassium Channels, Voltage-GatedSmoothened ReceptorGTP-Binding Protein alpha Subunits, Gi-GoHedgehog ProteinsPotassiumPotassium Channels, Voltage-GatedSmoothened ReceptorSmo protein, mouseaction potentialarrhythmiascardiovascularG proteinG protein-coupled receptor (GPCR)heartHedgehog signaling pathwayion channelnoncanonicalpotassium channelSmoothened

Identifiers

PMID29802197
PMCPMC6052211
OpenAlexW2804905286

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.