Evidence map›Paper›PMID 29802140›Full record

ArticleThe Journal of biological chemistry2018

Notch inhibitor screening reveals an unexpected HES1 heterodimer.

Krizia Rohena-Rivera, Neil A Bhowmick

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Krizia Rohena-RiveraDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Neil A BhowmickDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Research, Greater Los Angeles Veterans Affairs Hospital, Los Angeles, California 90048. Electronic address: bhowmickn@cshs.org.
Cedars-Sinai Medical Center · US

Funding

Prostate Cancer Bone Metastasis: Biology and TargetingP01CA098912 · NCI · EMORY UNIVERSITY · PI TIGHIOUART, MOURAD · 2003 to 2019
$24.0M
Training Program in Endocrinology, Diabetes, and MetabolismT32DK007770 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI MELMED, SHLOMO · 1999 to 2022
$3.4M
Paracrine Mechanisms of Prostate Cancer Metastatic ProgressionI01BX001040 · VA · VETERANS HEALTH ADMINISTRATION · PI BHOWMICK, NEIL A. · 2013 to 2020
–
BLRD VA I01 BX001040NCI NIH HHS P01 CA098912NIDDK NIH HHS T32 DK007770
6 · The paper itself

Abstract

Notch signaling plays critical roles in cancer progression, motivating efforts to identify inhibitors of this pathway. Perron

Indexed as

High-Throughput Screening AssaysAntineoplastic AgentsHumansNeoplasmsProtein MultimerizationReceptors, NotchSmall Molecule LibrariesTranscription Factor HES-1Antineoplastic AgentsHES1 protein, humanReceptors, NotchSmall Molecule LibrariesTranscription Factor HES-1

Identifiers

PMID29802140
PMCPMC5971460
OpenAlexW2803329307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.