Evidence map›Paper›PMID 29802128›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

A

Jorgen Kjaergaard, Stephen Hatfield, Graham Jones, Akio Ohta, Michail Sitkovsky

Abstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 126 citations in OpenAlex.

  1. Review
  2. Review
  3. Dual blockade of adenosine AFrontiers in immunology · 2026
    Article
  4. T cell exhaustion in parasitic infections.Frontiers in immunology · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Purinergic Signaling in Ovarian Carcinoma.Advanced pharmaceutical bulletin · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jorgen KjaergaardNew England Inflammation and Tissue Protection Institute, Northeastern University, Boston, MA 02115; and.ORCID 0000-0003-3547-3054
Stephen HatfieldNew England Inflammation and Tissue Protection Institute, Northeastern University, Boston, MA 02115; and m.sitkovsky@neu.edu s.hatfield@neu.edu.ORCID 0000-0002-2937-2268
Graham JonesDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115.ORCID 0000-0003-2195-3567
Akio OhtaNew England Inflammation and Tissue Protection Institute, Northeastern University, Boston, MA 02115; and.
Michail SitkovskyNew England Inflammation and Tissue Protection Institute, Northeastern University, Boston, MA 02115; and m.sitkovsky@neu.edu s.hatfield@neu.edu.ORCID 0000-0002-9819-9729
Northeastern University · US

Funding

Cancer Immunotherapy by Targeting A2 Adenosine ReceptorR01CA111985 · NCI · NORTHEASTERN UNIVERSITY · PI SITKOVSKY, MICHAIL · 2006 to 2016
$2.7M
Mechanisms of Tumor Protection for T Cells by HypoxiaR01CA112561 · NCI · NORTHEASTERN UNIVERSITY · PI SITKOVSKY, MICHAIL · 2005 to 2009
$1.5M
Hyperbaric Oxygenation May Increase Lung InjuryR21AT002788 · NCCIH · NORTHEASTERN UNIVERSITY · PI SITKOVSKY, MICHAIL · 2006 to 2007
$387k
NCCIH NIH HHS R21 AT002788NCI NIH HHS R01 CA111985NCI NIH HHS R01 CA112561
6 · The paper itself

Abstract

Tumor hypoxia-driven accumulation of extracellular adenosine was shown to facilitate tumor evasion by engaging the immunosuppressive, intracellular cAMP-elevating A

Indexed as

AdenosineAdenosine A2 Receptor AntagonistsAnimalsBrain NeoplasmsCD8-Positive T-LymphocytesCell Line, TumorDisease Models, AnimalFemaleHumansHypoxiaImmune ToleranceImmunityImmunotherapy, AdoptiveMiceMice, Inbred C57BLMice, KnockoutAdenosineAdenosine A2 Receptor AntagonistsReceptor, Adenosine A2A

Identifiers

PMID29802128
PMCPMC6052792
OpenAlexW2804340288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.