Evidence map›Paper›PMID 29801461›Full record

ArticleVirology journal2018

HPV-16, HPV-58, and HPV-33 are the most carcinogenic HPV genotypes in Southwestern China and their viral loads are associated with severity of premalignant lesions in the cervix.

Wenbo Long, Zixi Yang, Xiabin Li, Ming Chen, Jie Liu, Yuanxue Zhang, Xingwang Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenbo LongPathology Department of the First Affiliated Hospital, Southwest Medical University, Taiping Street No.25, Jiangyang District, Luzhou City, Sichuan, China.
Zixi YangPathology Department of the First Affiliated Hospital, Southwest Medical University, Taiping Street No.25, Jiangyang District, Luzhou City, Sichuan, China.
Xiabin LiPathology Department of the First Affiliated Hospital, Southwest Medical University, Taiping Street No.25, Jiangyang District, Luzhou City, Sichuan, China.
Ming ChenPathology Department of the First Affiliated Hospital, Southwest Medical University, Taiping Street No.25, Jiangyang District, Luzhou City, Sichuan, China.
Jie LiuPathology Department of the First Affiliated Hospital, Southwest Medical University, Taiping Street No.25, Jiangyang District, Luzhou City, Sichuan, China.
Yuanxue ZhangPathology Department of the First Affiliated Hospital, Southwest Medical University, Taiping Street No.25, Jiangyang District, Luzhou City, Sichuan, China.
Xingwang SunPathology Department of the First Affiliated Hospital, Southwest Medical University, Taiping Street No.25, Jiangyang District, Luzhou City, Sichuan, China. xingwangsun@126.com.

Funding

PhD Research Fund of the Affiliated Hospital of Southwest Medical University, 16238the Luzhou city - Southwest Medical University Joint Project 2017LZXNYD-PO2
6 · The paper itself

Abstract

backgroundCurrently, the role of human papillomavirus (HPV)-58 in southwestern China has been unexplored. Although there is some controversy, it is proposed that the viral load of HPV correlates with the severity of intraepithelial lesions.

methodsWe identified 7747 patients from south Sichuan and adjacent regions who were diagnosed with HPV between 2013 and 2017. The HR-HPV subtype distribution was analyzed and the patient's viral loads were quantified using real-time RT-PCR.

resultsAmong all 7747 patients screened for HPV genotypes, 1728 patients (22.31%) were identified as having HR-HPV subtypes. In patients without intraepithelial lesions (12.41%), HPV-52, HPV-16, and HPV-58 were the three most prevalent HR-HPV subtypes. Moreover, HPV-16, HPV-58, and HPV-33 were the most prevalent subtypes in patients with cervical intraepithelial neoplasia grade II (CINII) (42.86%) and grade III (CINIII) (59.81%), and accounted for the majority of invasive cervical cancer (ICC) (69.34%). Thus, viral loads of HPV-58, HPV-16, and HPV-33 positively correlated with the severity of cervical lesions (P < 0.001, P = 0.016, P = 0.026, respectively). Using receiver operating characteristic (ROC) curve analysis, the optimum thresholds for predicting severe intraepithelial lesions of cases (CINI, CINIII and ICC) with HPV-16, HPV-58, and HPV-33, respectively, were obtained, which were 1, 0.93, and 0.25, respectively.

conclusionIn our study, we showed that HPV-16 was the most common carcinogenic HPV subtype in southwestern China followed by HPV-58 and HPV-33. Viral loads of these subtypes are associated with the severity of premalignant lesions in the cervix.

Indexed as

AdolescentAdultAgedAged, 80 and overAlphapapillomavirusCervix UteriChinaFemaleGenotypeHuman papillomavirus 16HumansMiddle AgedNeoplasm GradingPapillomavirus InfectionsPrecancerous ConditionsReal-Time Polymerase Chain ReactionCorrelation analysisHigh-risk HPV subtypeHuman Papillomavirus (HPV)Intraepithelial lesionViral load

Identifiers

PMID29801461
PMCPMC5970451

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.