Evidence map›Paper›PMID 29800949›Full record

SynthesisJAMA psychiatry2018

Comparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis: A Systematic Review, Meta-analysis, and Meta-regression.

Christoph U Correll, Britta Galling, Aditya Pawar, Anastasia Krivko, Chiara Bonetto, Mirella Ruggeri, Thomas J Craig, Merete Nordentoft, Vinod H Srihari, Sinan Guloksuz and 16 more

5 registry-linked trialsAbstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in JAMA psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 383 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
383citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04273685 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Cognitive Remediation and Social Recovery in Early Psychosis

TypeinterventionalSponsorNational University of Ireland, Galway, IrelandRan2019 to 2022Enrolled40ConditionsPsychosisArmsCognitive remediation training, social recovery therapy, treatment as usual
NCT06563466 narecruitingnot on this mapstarted 2024, after this paper: background citation

PEGASUS - Improving Treatment for Patients With Emotionally Unstable Personality Disorder

TypeinterventionalSponsorUniversity Hospital Bispebjerg and FrederiksbergRan2024 to 2029Enrolled100ConditionsBorderline Personality Disorder, RelativesArmsThe experimental intervention PEGASUS, Treatment as usual
NCT06653829 nacompletednot on this mapstarted 2023, after this paper: background citation

NST-SPARK: Preliminary Study of an Augmented Reality (AR) App Delivering Recovery-Oriented Cognitive Therapy for Negative Symptoms in Schizophrenia

TypeinterventionalSponsorNorth Shore Therapeutics, Inc.Ran2023 to 2024Enrolled20ConditionsNegative Symptoms in Schizophrenia, Schizophrenia, Schizoaffective DisorderArmsSPARK
NCT07213492 narecruitingnot on this mapstarted 2026, after this paper: background citation

A Bridge to Better Days: A Pilot Study of a Multimodal Intervention to Support the Successful Transition From Hospital to Community Care for People Living With Bipolar Disorder

TypeinterventionalSponsorMcMaster UniversityRan2026 to 2027Enrolled10ConditionsBipolar Disorder (BD), PsychosisArmsGroup-Based Psychoeducation, Peer Support, Personalized Support for Community Healthcare Provider
NCT07713849 recruitingnot on this mapstarted 2026, after this paper: background citation

Adapting and Improving Transition Care for First Episode Psychosis

Typeobservational_patient_registrySponsorUniversity of ChicagoRan2026 to 2029Enrolled75ConditionsSchizoaffective Disorders, Bipolar Disorder With Psychotic Features, Schizophrenia Disorders, Major Depressive Disorder With Psychotic FeaturesArmsTransition Care Team
3 · Its place in the literature

Who cites it

383 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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323 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Christoph U CorrellDepartment of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York.
Britta GallingDepartment of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York.
Aditya PawarDepartment of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York.
Anastasia KrivkoDepartment of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York.
Chiara BonettoSection of Psychiatry, Department of Public Health and Community Medicine, University of Verona, Verona, Italy.
Mirella RuggeriSection of Psychiatry, Department of Public Health and Community Medicine, University of Verona, Verona, Italy.
Thomas J CraigInstitute of Psychiatry, King's College London, London, England.
Merete NordentoftMental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.
Vinod H SrihariDepartment of Psychiatry, Yale University, New Haven, Connecticut.
Sinan GuloksuzDepartment of Psychiatry, Yale University, New Haven, Connecticut.
Christy L M HuiDepartment of Psychiatry, University of Hong Kong, Hong Kong, China.
Eric Y H ChenDepartment of Psychiatry, University of Hong Kong, Hong Kong, China.
Marcelo ValenciaDivision of Epidemiological and Psychosocial Research, National Institute of Psychiatry, Mexico City, Mexico.
Francisco JuarezDivision of Epidemiological and Psychosocial Research, National Institute of Psychiatry, Mexico City, Mexico.
Delbert G RobinsonDepartment of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York.
Nina R SchoolerDepartment of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York.
Mary F BrunetteDepartment of Psychiatry, Geisel School of Medicine at Dartmouth, Dartmouth, New Hampshire.
Kim T MueserDepartment of Occupational Therapy, Center for Psychiatric Rehabilitation, Boston University, Boston, Massachusetts.
Robert A RosenheckDepartment of Psychiatry, Yale University, New Haven, Connecticut.
Patricia MarcyDepartment of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York.
Jean AddingtonThe Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
Sue E EstroffDepartment of Social Medicine, The University of North Carolina at Chapel Hill.
James RobinsonNathan Kline Institute, Orangeburg, New York.
David PennDepartment of Psychology, The University of North Carolina at Chapel Hill.
Joanne B SevereNational Institute of Mental Health (NIMH), Bethesda, Maryland.
John M KaneDepartment of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York.

Funding

Trials Operation Unit (OPERATIONS CORE)P30MH090590 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CORRELL, CHRISTOPH U · 2010 to 2014
$7.9M
NIMH NIH HHS P30 MH090590
6 · The paper itself

Abstract

Importance: The value of early intervention in psychosis and allocation of public resources has long been debated because outcomes in people with schizophrenia spectrum disorders have remained suboptimal. Objective: To compare early intervention services (EIS) with treatment as usual (TAU) for early-phase psychosis. Data Sources: Systematic literature search of PubMed, PsycINFO, EMBASE, and ClinicalTrials.gov without language restrictions through June 6, 2017. Study Selection: Randomized trials comparing EIS vs TAU in first-episode psychosis or early-phase schizophrenia spectrum disorders. Data Extraction and Synthesis: This systematic review was conducted according to PRISMA guidelines. Three independent investigators extracted data for a random-effects meta-analysis and prespecified subgroup and meta-regression analyses. Main Outcomes and Measures: The coprimary outcomes were all-cause treatment discontinuation and at least 1 psychiatric hospitalization during the treatment period. Results: Across 10 randomized clinical trials (mean [SD] trial duration, 16.2 [7.4] months; range, 9-24 months) among 2176 patients (mean [SD] age, 27.5 [4.6] years; 1355 [62.3%] male), EIS was associated with better outcomes than TAU at the end of treatment for all 13 meta-analyzable outcomes. These outcomes included the following: all-cause treatment discontinuation (risk ratio [RR], 0.70; 95% CI, 0.61-0.80; P < .001), at least 1 psychiatric hospitalization (RR, 0.74; 95% CI, 0.61-0.90; P = .003), involvement in school or work (RR, 1.13; 95% CI, 1.03-1.24; P = .01), total symptom severity (standardized mean difference [SMD], -0.32; 95% CI, -0.47 to -0.17; P < .001), positive symptom severity (SMD, -0.22; 95% CI, -0.32 to -0.11; P < .001), and negative symptom severity (SMD, -0.28; 95% CI, -0.42 to -0.14; P < .001). Superiority of EIS regarding all outcomes was evident at 6, 9 to 12, and 18 to 24 months of treatment (except for general symptom severity and depressive symptom severity at 18-24 months). Conclusions and Relevance: In early-phase psychosis, EIS are superior to TAU across all meta-analyzable outcomes. These results support the need for funding and use of EIS in patients with early-phase psychosis.

Indexed as

Schizophrenic PsychologyEarly Medical InterventionEducationEmploymentHospitalizationHumansPsychotic DisordersRandomized Controlled Trials as TopicRegression AnalysisSchizophreniaSeverity of Illness Index

Identifiers

PMID29800949
PMCPMC6137532

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.